Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aao4827 |
Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission | |
Rice, Heather C.1,2; de Malmazet, Daniel3,4; Schreurs, An5; Frere, Samuel6,7; Van Molle, Inge8; Volkov, Alexander N.8,9; Creemers, Eline1,2; Vertkin, Irena6,7; Nys, Julie1,2; Ranaivoson, Fanomezana M.10,16; Comoletti, Davide10,11,17; Savas, Jeffrey N.12; Remaut, Han8; Balschun, Detlef5; Wierda, Keimpe D.1,2; Slutsky, Inna6,7; Farrow, Karl3,4,13,14; De Strooper, Bart1,2,15; de Wit, Joris1,2 | |
2019-01-11 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6423页码:143-143 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium; Israel; USA; England; France; New Zealand |
英文摘要 | Amyloid-beta precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor for secreted APP (sAPP). Here we show that the sAPP extension domain directly bound the sushi 1 domain specific to the gamma-aminobutyric acid type B receptor subunit 1a (GABA(B)R1a). sAPP-GABA(B)R1a binding suppressed synaptic transmission and enhanced short-term facilitation in mouse hippocampal synapses via inhibition of synaptic vesicle release. A 17-amino acid peptide corresponding to the GABA(B)R1a binding region within APP suppressed in vivo spontaneous neuronal activity in the hippocampus of anesthetized Thy1-GCaMP6s mice. Our findings identify GABA(B)R1a as a synaptic receptor for sAPP and reveal a physiological role for sAPP in regulating GABA(B)R1a function to modulate synaptic transmission. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455320600040 |
WOS关键词 | LONG-TERM POTENTIATION ; PHYSIOLOGICAL FUNCTIONS ; PRESYNAPTIC INHIBITION ; RECEPTOR ANTAGONIST ; MOLECULAR-STRUCTURE ; NEURONAL-ACTIVITY ; MICE LACKING ; APPS-ALPHA ; REVEALS ; RELEASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200517 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.VIB Ctr Brain & Dis Res, Leuven, Belgium; 2.Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci, Leuven, Belgium; 3.Neuroelect Res Flanders, Leuven, Belgium; 4.Katholieke Univ Leuven, Leuven Brain Inst, Dept Biol, Leuven, Belgium; 5.Katholieke Univ Leuven, Brain & Cognit, Leuven, Belgium; 6.Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, Tel Aviv, Israel; 7.Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel; 8.VIB VUB, Struct Biol Res Ctr, Brussels, Belgium; 9.VUB, Jean Jeener NMR Ctr, Brussels, Belgium; 10.Rutgers State Univ, Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ USA; 11.Rutgers State Univ, Dept Neurosci & Cell Biol, Robert Wood Johnson Med Sch, New Brunswick, NJ USA; 12.Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA; 13.VIB, Leuven, Belgium; 14.Imec, Leuven, Belgium; 15.UCL, UK Dementia Res Inst, London, England; 16.PSL Res Univ, CNRS, UMR 144, Struct Motil,Inst Curie, Paris, France; 17.Victoria Univ Wellington, Sch Biol Sci, Wellington, New Zealand |
推荐引用方式 GB/T 7714 | Rice, Heather C.,de Malmazet, Daniel,Schreurs, An,et al. Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission[J]. SCIENCE,2019,363(6423):143-143. |
APA | Rice, Heather C..,de Malmazet, Daniel.,Schreurs, An.,Frere, Samuel.,Van Molle, Inge.,...&de Wit, Joris.(2019).Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission.SCIENCE,363(6423),143-143. |
MLA | Rice, Heather C.,et al."Secreted amyloid-beta precursor protein functions as a GABA(B)R1a ligand to modulate synaptic transmission".SCIENCE 363.6423(2019):143-143. |
条目包含的文件 | 条目无相关文件。 |
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