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DOI | 10.1126/science.aav0502 |
Emergence of preconfigured and plastic time-compressed sequences in early postnatal development | |
Farooq, U.1; Dragoi, G.1,2,3 | |
2019-01-11 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 363期号:6423页码:168-173 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | When and how hippocampal neuronal ensembles first organize to support encoding and consolidation of memory episodes, a critical cognitive function of the brain, are unknown. We recorded electrophysiological activity from large ensembles of hippocampal neurons starting on the first day after eye opening as naive rats navigated linear environments and slept. We found a gradual age-dependent, navigational experience-independent assembly of preconfigured trajectory-like sequences from persistent, location-depicting ensembles during postnatal week 3. Adult-like compressed binding of adjacent locations into trajectories during navigation and their navigational experience-dependent replay during sleep emerged in concert from spontaneous preconfigured sequences only during early postnatal week 4. Our findings reveal ethologically relevant distinct phases in the development of hippocampal preconfigured and experience-dependent sequential patterns thought to be important for episodic memory formation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000455320600049 |
WOS关键词 | MEDIAL ENTORHINAL CORTEX ; HIPPOCAMPAL PLACE CELLS ; MEMORY ; REPLAY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/200502 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Sch Med, Interdept Neurosci Program, New Haven, CT 06510 USA; 2.Yale Sch Med, Dept Psychiat, New Haven, CT 06510 USA; 3.Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA |
推荐引用方式 GB/T 7714 | Farooq, U.,Dragoi, G.. Emergence of preconfigured and plastic time-compressed sequences in early postnatal development[J]. SCIENCE,2019,363(6423):168-173. |
APA | Farooq, U.,&Dragoi, G..(2019).Emergence of preconfigured and plastic time-compressed sequences in early postnatal development.SCIENCE,363(6423),168-173. |
MLA | Farooq, U.,et al."Emergence of preconfigured and plastic time-compressed sequences in early postnatal development".SCIENCE 363.6423(2019):168-173. |
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