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GSTDTAP  > 地球科学
DOI10.1126/science.aat7615
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
Li, Mingfeng1; 39;Donovan, Michael C.2
2018-12-14
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号362期号:6420页码:1264-+
文章类型Article
语种英语
国家USA; South Korea; Netherlands; Wales; Turkey; England; Peoples R China; Sweden
英文摘要

To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000452994400041
WOS关键词SINGLE-CELL ANALYSIS ; DE-NOVO MUTATIONS ; DNA METHYLATION ; SUSCEPTIBILITY LOCI ; EXPRESSION ANALYSIS ; MENTAL-RETARDATION ; READ ALIGNMENT ; TRANSCRIPTOME ; ASSOCIATION ; ARCHITECTURE
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/200320
专题地球科学
资源环境科学
气候变化
作者单位1.Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA;
2.Yale Sch Med, Kavli Inst Neurosci, New Haven, CT 06510 USA;
3.Penn State Univ, Coll Med, Dept Pharmacol, Inst Personalized Med, Hershey, PA USA;
4.Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Inst Personalized Med, Hershey, PA USA;
5.Suny Downstate Med Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA;
6.Allen Inst Brain Sci, Seattle, WA 98109 USA;
7.Natl Res Fdn Korea, Daejeon, South Korea;
8.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA;
9.Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA;
10.Yale Sch Med, Dept Psychiat, New Haven, CT 06510 USA;
11.Chung Ang Univ, Dept Life Sci, Seoul, South Korea;
12.Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA;
13.SUNY Stony Brook, Dept Biomed Informat, Stony Brook, NY 11794 USA;
14.Univ N Carolina, Dept Genet, Chapel Hill, NC USA;
15.Univ N Carolina, UNC Neurosci Ctr, Chapel Hill, NC 27599 USA;
16.Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam, Netherlands;
17.Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, MRC Ctr Neuropsychiat Genet & Gen, Cardiff, S Glam, Wales;
18.Cleveland Clin Fdn, Lerner Res Inst, Dept Quantitat Hlth Sci, 9500 Euclid Ave, Cleveland, OH 44195 USA;
19.Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA;
20.Univ N Carolina, Dept Biostat, Chapel Hill, NC USA;
21.USC, Mind Keck Sch Med, Inst Developing, Dept Pediat, Los Angeles, CA USA;
22.Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA;
23.Johns Hopkins Med Campus, Lieber Inst Brain Dev, Baltimore, MD USA;
24.Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA;
25.Univ Calif Los Angeles, David Geffen Sch Med, Program Neurobehav Genet, Ctr Autism Res & Treatment,Semel Inst, Los Angeles, CA 90095 USA;
26.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA;
27.Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA;
28.Yale Univ, Dept Comp Sci, POB 2158, New Haven, CT 06520 USA;
29.Yale Univ, Dept Stat & Data Sci, New Haven, CT 06520 USA;
30.Yale Sch Med, Dept Genet, New Haven, CT 06510 USA;
31.Yale Sch Med, Program Integrat Cell Signaling & Neurobiol Metab, Dept Comparat Med, New Haven, CT 06510 USA;
32.Yale Sch Med, Program Cellular Neurosci Neurodegenerat & Repair, New Haven, CT 06510 USA;
33.Yale Sch Med, Yale Child Study Ctr, New Haven, CT 06510 USA;
34.Yale Univ, New Haven, Turkey;
35.Lieber Inst Brain Dev, Baltimore, MD USA;
36.Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England;
37.Univ Southern Calif, Los Angeles, CA USA;
38.Univ Calif Los Angeles, Los Angeles, CA USA;
39.Michigan State Univ, E Lansing, MI 48824 USA;
40.Mayo Clin, Rochester, MN USA;
41.Icahn Sch Med Mt Sinai, New York, NY 10029 USA;
42.Duke Univ, Durham, NC USA;
43.Johns Hopkins Univ, Baltimore, MD USA;
44.Suny Downstate Med Ctr, Brooklyn, NY 11203 USA;
45.SUNY Upstate Med Univ, Syracuse, NY 13210 USA;
46.Univ Calif San Francisco, San Francisco, CA 94143 USA;
47.Univ N Carolina, Chapel Hill, NC 27515 USA;
48.Univ Massachusetts, Med Sch, Amherst, MA 02125 USA;
49.Univ Chicago, Chicago, IL 60637 USA;
50.Banner Sun Hlth Res Inst, Sun City, AZ USA;
51.Univ Penn, Philadelphia, PA 19104 USA;
52.James J Peters VA Med Ctr, Bronx, NY USA;
53.Univ Pittsburgh, Pittsburgh, PA USA;
54.NIH, Human Brain Collect Core, Bethesda, MD USA;
55.St Jude Childrens Res Hosp, Knoxville, TN USA;
56.Cent S Univ, Changsha, Hunan, Peoples R China;
57.Stanley Med Res Inst, Rockville, MD USA;
58.Karolinska Inst, Huddinge, Sweden;
59.Univ Illinois, Chicago, IL USA;
60.Sage Bionetworks, Seattle, WA USA;
61.Univ Washington, Seattle, WA 98195 USA
推荐引用方式
GB/T 7714		 Li, Mingfeng,39;Donovan, Michael C.. Integrative functional genomic analysis of human brain development and neuropsychiatric risks[J]. SCIENCE,2018,362(6420):1264-+.
APA Li, Mingfeng,&39;Donovan, Michael C..(2018).Integrative functional genomic analysis of human brain development and neuropsychiatric risks.SCIENCE,362(6420),1264-+.
MLA Li, Mingfeng,et al."Integrative functional genomic analysis of human brain development and neuropsychiatric risks".SCIENCE 362.6420(2018):1264-+.
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