GSTDTAP  > 地球科学
DOI10.1126/science.aao3791
Single-cell multiomics sequencing and analyses of human colorectal cancer
Bian, Shuhui1,2,3,4; Hou, Yu1,2,3; Zhou, Xin5; Li, Xianlong1,2,3; Yong, Jun1,6; Wang, Yicheng1,2,3; Wang, Wendong5; Yan, Jia1,2,3; Hu, Boqiang1,2,3; Guo, Hongshan1,2,3; Wang, Jilian5; Gao, Shuai1,2,3; Mao, Yunuo1,2,3; Dong, Ji1,2,3; Zhu, Ping1,2,3,4; Xiu, Dianrong5; Yan, Liying1,6; Wen, Lu1,2,3; Qiao, Jie1,4,6,7; Tang, Fuchou1,2,3,4; Fu, Wei5
2018-11-30
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2018
卷号362期号:6418页码:1060-+
文章类型Article
语种英语
国家Peoples R China
英文摘要

Although genomic instability, epigenetic abnormality, and gene expression dysregulation are hallmarks of colorectal cancer, these features have not been simultaneously analyzed at single-cell resolution. Using optimized single-cell multiomics sequencing together with multiregional sampling of the primary tumor and lymphatic and distant metastases, we developed insights beyond intratumoral heterogeneity. Genome-wide DNA methylation levels were relatively consistent within a single genetic sublineage. The genome-wide DNA demethylation patterns of cancer cells were consistent in all 10 patients whose DNA we sequenced. The cancer cells' DNA demethylation degrees clearly correlated with the densities of the heterochromatin-associated histone modification H3K9me3 of normal tissue and those of repetitive element long interspersed nuclear element 1. Our work demonstrates the feasibility of reconstructing genetic lineages and tracing their epigenomic and transcriptomic dynamics with single-cell multiomics sequencing.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000451609000047
WOS关键词HETEROGENEITY ; TRANSCRIPTOME ; LANDSCAPE ; EVOLUTION ; IMPACT
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/200208
专题地球科学
资源环境科学
气候变化
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing Adv Innovat Ctr Genom,Coll Life Sci, Beijing 100871, Peoples R China;
2.Minist Educ, Key Lab Cell Proliferat & Differentiat, Biomed Pioneering Innovat Ctr, Beijing 100871, Peoples R China;
3.Minist Educ, Key Lab Cell Proliferat & Differentiat, Ctr Reprod Med, Beijing 100871, Peoples R China;
4.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China;
5.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China;
6.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China;
7.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Bian, Shuhui,Hou, Yu,Zhou, Xin,et al. Single-cell multiomics sequencing and analyses of human colorectal cancer[J]. SCIENCE,2018,362(6418):1060-+.
APA Bian, Shuhui.,Hou, Yu.,Zhou, Xin.,Li, Xianlong.,Yong, Jun.,...&Fu, Wei.(2018).Single-cell multiomics sequencing and analyses of human colorectal cancer.SCIENCE,362(6418),1060-+.
MLA Bian, Shuhui,et al."Single-cell multiomics sequencing and analyses of human colorectal cancer".SCIENCE 362.6418(2018):1060-+.
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