An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

doi:10.1126/science.aat8923

GSTDTAP > 地球科学

DOI	10.1126/science.aat8923
	An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
	Gong, Hongri 1,2; Li, Jun 3,4; Xu, Ao 1,2,5; Tang, Yanting 1,2; Ji, Wenxin 5,6; Gao, Ruogu 5,6; Wang, Shuhui 3,4; Yu, Lu 7; Tian, Changlin 7,8,9; Li, Jingwen 10; Yen, Hsin-Yung 10,11; Lam, Sin Man 12; Shui, Guanghou 12; Yang, Xiuna 3,4; Sun, Yuna 5; Li, Xuemei 5; Jia, Minze 5; Yang, Cheng 1,2; Jiang, Biao 3; Lou, Zhiyong 13; Robinson, Carol V.10; Wong, Luet-Lok 14; Guddat, Luke W.15; Sun, Fei 5,6; Wang, Quan 5; Rao, Zihe 1,2,3,4,5,13
	2018-11-30
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	362 期号:6418 页码:1020-+
文章类型	Article
语种	英语
国家	Peoples R China; England; Australia
英文摘要	We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000451609000036
WOS关键词	CYTOCHROME-C-OXIDASE ; CU,ZN SUPEROXIDE-DISMUTASE ; BEAM-INDUCED MOTION ; PARACOCCUS-DENITRIFICANS ; CRYSTAL-STRUCTURE ; SUPRAMOLECULAR ORGANIZATION ; CORYNEBACTERIUM-GLUTAMICUM ; TERMINAL OXIDASE ; COMPLEX ; TUBERCULOSIS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200198
专题	地球科学资源环境科学气候变化
作者单位	1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300353, Peoples R China; 2.Nankai Univ, Coll Life Sci, Tianjin 300353, Peoples R China; 3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China; 6.Univ Chinese Acad Sci, Beijing, Peoples R China; 7.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China; 8.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China; 9.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China; 10.Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, South Parks Rd, Oxford OX1 3QZ, England; 11.OMass Technol, Begbroke Sci Pk,Woodstock Rd, Yarnton OX5 1PF, Kidlington, England; 12.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China; 13.Tsinghua Univ, Lab Struct Biol, Beijing 100084, Peoples R China; 14.Univ Oxford, Inorgan Chem Lab, Dept Chem, South Parks Rd, Oxford OX1 3QR, England; 15.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Gong, Hongri,Li, Jun,Xu, Ao,et al. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex[J]. SCIENCE,2018,362(6418):1020-+.
APA	Gong, Hongri.,Li, Jun.,Xu, Ao.,Tang, Yanting.,Ji, Wenxin.,...&Rao, Zihe.(2018).An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.SCIENCE,362(6418),1020-+.
MLA	Gong, Hongri,et al."An electron transfer path connects subunits of a mycobacterial respiratory supercomplex".SCIENCE 362.6418(2018):1020-+.