Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells

doi:10.1126/science.aau2909

GSTDTAP > 地球科学

DOI	10.1126/science.aau2909
	Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells
	Lienart, Stephanie 1; Merceron, Romain 2,3; Vanderaa, Christophe 1; Lambert, Fanny 1; Colau, Didier 4; Stockis, Julie 1,5; van der Woning, Bas 6; De Haard, Hans 6; Saunders, Michael 6; Coulie, Pierre G.1,5; Savvides, Savvas N.2,3; Lucas, Sophie 1,5
	2018-11-23
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	362 期号:6417 页码:952-+
文章类型	Article
语种	英语
国家	Belgium
英文摘要	Transforming growth factor-beta 1 (TGF-beta 1) is one of very few cytokines produced in a latent form, requiring activation to exert any of its vastly diverse effects on development, immunity, and cancer. Regulatory T cells (T-regs) suppress immune cells within close proximity by activating latent TGF-beta 1 presented by GARP (glycoprotein A repetitions predominant) to integrin alpha V beta 8 on their surface. We solved the crystal structure of GARP: latent TGF-beta 1 bound to an antibody that stabilizes the complex and blocks release of active TGF-beta 1. This finding reveals how GARP exploits an unusual medley of interactions, including fold complementation by the amino terminus of TGF-beta 1, to chaperone and orient the cytokine for binding and activation by alpha V beta 8. Thus, this work further elucidates the mechanism of antibody-mediated blockade of TGF-beta 1 activation and immunosuppression by T-regs.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000451124500044
WOS关键词	TGF-BETA ; PROTEINS ; SURFACE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/200134
专题	地球科学资源环境科学气候变化
作者单位	1.UCLouvain, de Duve Inst, B-1200 Brussels, Belgium; 2.Univ Ghent, Dept Biochem & Microbiol, B-9052 Ghent, Belgium; 3.VIB Ctr Inflammat Res, B-9052 Ghent, Belgium; 4.Ludwig Canc Res, Brussels, Belgium; 5.Walloon Excellence Lifesci & Biotechnol, B-1300 Wavre, Belgium; 6.Argenx, B-9052 Zwijnaarde, Belgium
推荐引用方式 GB/T 7714	Lienart, Stephanie,Merceron, Romain,Vanderaa, Christophe,et al. Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells[J]. SCIENCE,2018,362(6417):952-+.
APA	Lienart, Stephanie.,Merceron, Romain.,Vanderaa, Christophe.,Lambert, Fanny.,Colau, Didier.,...&Lucas, Sophie.(2018).Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.SCIENCE,362(6417),952-+.
MLA	Lienart, Stephanie,et al."Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells".SCIENCE 362.6417(2018):952-+.