Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aao6809 |
Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations | |
Kratochwil, Claudius F.1,2,3; Liang, Yipeng1; Gerwin, Jan1,3; Woltering, Joost M.1; Urban, Sabine1,3; Henning, Frederico1,4; Machado-Schiaffino, Gonzalo1,5; Hulsey, C. Darrin1,3; Meyer, Axel1,3 | |
2018-10-26 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6413页码:457-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Brazil; Spain |
英文摘要 | The color patterns of African cichlid fishes provide notable examples of phenotypic convergence. Across the more than 1200 East African rift lake species, melanic horizontal stripes have evolved numerous times. We discovered that regulatory changes of the gene agouti-related peptide 2 (agrp2) act as molecular switches controlling this evolutionarily labile phenotype. Reduced agrp2 expression is convergently associated with the presence of stripe patterns across species flocks. However, cis-regulatory mutations are not predictive of stripes across radiations, suggesting independent regulatory mechanisms. Genetic mapping confirms the link between the agrp2 locus and stripe patterns. The crucial role of agrp2 is further supported by a CRISPR-Cas9 knockout that reconstitutes stripes in a nonstriped cichlid. Thus, we unveil how a single gene affects the convergent evolution of a complex color pattern. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000450441900050 |
WOS关键词 | ADAPTIVE RADIATION ; PIGMENTATION ; MODEL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199936 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Konstanz, Dept Biol, Constance, Germany; 2.Univ Konstanz, Zukunftskolleg, Constance, Germany; 3.IMPRS OB, Max Planck Inst Ornithol, Constance, Germany; 4.Univ Fed Rio de Janeiro, Fed Univ Rio De Janeiro, Inst Biol, Dept Genet, Rio de Janeiro, Brazil; 5.Univ Oviedo, Dept Funct Biol, Area Genet, Oviedo, Spain |
推荐引用方式 GB/T 7714 | Kratochwil, Claudius F.,Liang, Yipeng,Gerwin, Jan,et al. Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations[J]. SCIENCE,2018,362(6413):457-+. |
APA | Kratochwil, Claudius F..,Liang, Yipeng.,Gerwin, Jan.,Woltering, Joost M..,Urban, Sabine.,...&Meyer, Axel.(2018).Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations.SCIENCE,362(6413),457-+. |
MLA | Kratochwil, Claudius F.,et al."Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations".SCIENCE 362.6413(2018):457-+. |
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