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DOI | 10.1126/science.aau3301 |
Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis | |
Shellard, Adam1; Szabo, Andras1; Trepat, Xavier2,3,4; Mayor, Roberto1 | |
2018-10-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 362期号:6412页码:339-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Spain |
英文摘要 | Collective cell chemotaxis, the directed migration of cell groups along gradients of soluble chemical cues, underlies various developmental and pathological processes. We use neural crest cells, a migratory embryonic stem cell population whose behavior has been likened to malignant invasion, to study collective chemotaxis in vivo. Studying Xenopus and zebrafish, we have shown that the neural crest exhibits a tensile actomyosin ring at the edge of the migratory cell group that contracts in a supracellular fashion. This contractility is polarized during collective cell chemotaxis: It is inhibited at the front but persists at the rear of the cell cluster. The differential contractility drives directed collective cell migration ex vivo and in vivo through the intercalation of rear cells. Thus, in neural crest cells, collective chemotaxis works by rear-wheel drive. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000447680100048 |
WOS关键词 | TISSUE MIGRATION ; IN-VIVO ; GUIDANCE ; POLARITY ; MORPHOGENESIS ; CADHERIN ; FORCES ; CANCER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199869 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.UCL, Dept Cell & Dev Biol, London WC1E 6BT, England; 2.BIST, Inst Bioengn Catalonia IBEC, Barcelona 08028, Spain; 3.Ctr Invest Biomed Red Bioingenieria Biomat & Nano, Barcelona 08028, Spain; 4.ICREA, Barcelona 08010, Spain |
推荐引用方式 GB/T 7714 | Shellard, Adam,Szabo, Andras,Trepat, Xavier,et al. Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis[J]. SCIENCE,2018,362(6412):339-+. |
APA | Shellard, Adam,Szabo, Andras,Trepat, Xavier,&Mayor, Roberto.(2018).Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis.SCIENCE,362(6412),339-+. |
MLA | Shellard, Adam,et al."Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis".SCIENCE 362.6412(2018):339-+. |
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