Response to Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification"

doi:10.1126/science.aat0958

GSTDTAP > 地球科学

DOI	10.1126/science.aat0958
	Response to Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification"
	Chen, Lixin; Liu, Pingfang; Evans, Thomas C., Jr.; Ettwiller, Laurence M.
	2018-09-28
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	361 期号:6409
文章类型	Editorial Material
语种	英语
国家	USA
英文摘要	Following the Comment of Stewart et al., we repeated our analysis on sequencing runs from The Cancer Genome Atlas (TCGA) using their suggested parameters. We found signs of oxidative damage in all sequence contexts and irrespective of the sequencing date, reaffirming that DNA damage affectsmutation-calling pipelines in their ability to accurately identify somatic variations.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000446142200002
WOS关键词	MUTATIONS
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/199686
专题	地球科学资源环境科学气候变化
作者单位	New England Biolabs Inc, Ipswich, MA 01938 USA
推荐引用方式 GB/T 7714	Chen, Lixin,Liu, Pingfang,Evans, Thomas C., Jr.,et al. Response to Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification"[J]. SCIENCE,2018,361(6409).
APA	Chen, Lixin,Liu, Pingfang,Evans, Thomas C., Jr.,&Ettwiller, Laurence M..(2018).Response to Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification".SCIENCE,361(6409).
MLA	Chen, Lixin,et al."Response to Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification"".SCIENCE 361.6409(2018).