Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aat8950 |
Chromatin plasticity: A versatile landscape that underlies cell fate and identity | |
Yadav, Tejas; Quivy, Jean-Pierre; Almouzni, Genevieve | |
2018-09-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6409页码:1332-+ |
文章类型 | Review |
语种 | 英语 |
国家 | France |
英文摘要 | During development and throughout life, a variety of specialized cells must be generated to ensure the proper function of each tissue and organ. Chromatin plays a key role in determining cellular state, whether totipotent, pluripotent, multipotent, or differentiated. We highlight chromatin dynamics involved in the generation of pluripotent stem cells as well as their influence on cell fate decision and reprogramming. We focus on the capacity of histone variants, chaperones, modifications, and heterochromatin factors to influence cell identity and its plasticity. Recent technological advances have provided tools to elucidate the underlying chromatin dynamics for a better understanding of normal development and pathological conditions, with avenues for potential therapeutic application. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446142200040 |
WOS关键词 | EARLY MAMMALIAN DEVELOPMENT ; TO-ZYGOTIC TRANSITION ; EMBRYONIC STEM-CELLS ; DNA METHYLATION ; PREIMPLANTATION EMBRYOS ; EPIGENETIC CONTROL ; MOUSE OOCYTES ; HISTONE ; REPLICATION ; H3K4ME3 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199680 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Inst Curie, F-75248 Paris 05, France |
推荐引用方式 GB/T 7714 | Yadav, Tejas,Quivy, Jean-Pierre,Almouzni, Genevieve. Chromatin plasticity: A versatile landscape that underlies cell fate and identity[J]. SCIENCE,2018,361(6409):1332-+. |
APA | Yadav, Tejas,Quivy, Jean-Pierre,&Almouzni, Genevieve.(2018).Chromatin plasticity: A versatile landscape that underlies cell fate and identity.SCIENCE,361(6409),1332-+. |
MLA | Yadav, Tejas,et al."Chromatin plasticity: A versatile landscape that underlies cell fate and identity".SCIENCE 361.6409(2018):1332-+. |
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