Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aau0320 |
Developmental enhancers and chromosome topology | |
Furlong, Eileen E. M.1; Levine, Michael2,3 | |
2018-09-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6409页码:1341-1345 |
文章类型 | Review |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | Developmental enhancers mediate on/off patterns of gene expression in specific cell types at particular stages during metazoan embryogenesis. They typically integrate multiple signals and regulatory determinants to achieve precise spatiotemporal expression. Such enhancers can map quite far-one megabase or more-from the genes they regulate. How remote enhancers relay regulatory information to their target promoters is one of the central mysteries of genome organization and function. A variety of contrasting mechanisms have been proposed over the years, including enhancer tracking, linking, looping, and mobilization to transcription factories. We argue that extreme versions of these mechanisms cannot account for the transcriptional dynamics and precision seen in living cells, tissues, and embryos. We describe emerging evidence for dynamic three-dimensional hubs that combine different elements of the classical models. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000446142200042 |
WOS关键词 | CHROMATIN DOMAINS ; REMOTE ENHANCERS ; CTCF ; GENOME ; TRANSCRIPTION ; ORGANIZATION ; PROMOTER ; GENE ; INSULATION ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199677 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.EMBL, Genome Biol Unit, D-69117 Heidelberg, Germany; 2.Lewis Sigler Inst Integrat Genom, Princeton, NJ 08540 USA; 3.Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA |
推荐引用方式 GB/T 7714 | Furlong, Eileen E. M.,Levine, Michael. Developmental enhancers and chromosome topology[J]. SCIENCE,2018,361(6409):1341-1345. |
APA | Furlong, Eileen E. M.,&Levine, Michael.(2018).Developmental enhancers and chromosome topology.SCIENCE,361(6409),1341-1345. |
MLA | Furlong, Eileen E. M.,et al."Developmental enhancers and chromosome topology".SCIENCE 361.6409(2018):1341-1345. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论