Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah4065 |
Apoptosis propagates through the cytoplasm as trigger waves | |
Cheng, Xianrui1; Ferrell, James E., Jr.1,2 | |
2018-08-10 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 361期号:6402页码:607-612 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Apoptosis is an evolutionarily conserved form of programmed cell death critical for development and tissue homeostasis in animals. The apoptotic control network includes several positive feedback loops that may allow apoptosis to spread through the cytoplasm in self-regenerating trigger waves. We tested this possibility in cell-free Xenopus laevis egg extracts and observed apoptotic trigger waves with speeds of similar to 30 micrometers per minute. Fractionation and inhibitor studies implicated multiple feedback loops in generating the waves. Apoptotic oocytes and eggs exhibited surface waves with speeds of similar to 30 micrometers per minute, which were tightly correlated with caspase activation. Thus, apoptosis spreads through trigger waves in both extracts and intact cells. Our findings show how apoptosis can spread over large distances within a cell and emphasize the general importance of trigger waves in cell signaling. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000441202700039 |
WOS关键词 | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION ; CYTOCHROME-C ; CELL-DEATH ; RELEASE ; BCL-2 ; CASPASE-3 ; DYNAMICS ; EXTRACTS ; CYCLE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/199341 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Cheng, Xianrui,Ferrell, James E., Jr.. Apoptosis propagates through the cytoplasm as trigger waves[J]. SCIENCE,2018,361(6402):607-612. |
APA | Cheng, Xianrui,&Ferrell, James E., Jr..(2018).Apoptosis propagates through the cytoplasm as trigger waves.SCIENCE,361(6402),607-612. |
MLA | Cheng, Xianrui,et al."Apoptosis propagates through the cytoplasm as trigger waves".SCIENCE 361.6402(2018):607-612. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论