Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells

doi:10.1126/science.aan5931

GSTDTAP > 地球科学

DOI	10.1126/science.aan5931
	Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
	Ma, Chi 1; Han, Miaojun 1; Heinrich, Bernd 1; Fu, Qiong 1; Zhang, Qianfei 1; Sandhu, Milan 1; Agdashian, David 1; Terabe, Masaki 2; Berzofsky, Jay A.2; Fako, Valerie 3; Ritz, Thomas 4; Longerich, Thomas 4,5; Theriot, Casey M.6; McCulloch, John A.7; Roy, Soumen 7; Yuan, Wuxing 7,8; Thovarai, Vishal 7,8; Sen, Shurjo K.7,8; Ruchirawat, Mathuros 9; Korangy, Firouzeh 1; Wang, Xin Wei 3,10; Trinchieri, Giorgio 7; Greten, Tim F.1,10
	2018-05-25
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2018
卷号	360 期号:6391
文章类型	Article
语种	英语
国家	USA; Germany; Thailand
英文摘要	Primary liver tumors and liver metastasis currently represent the leading cause of cancer-related death. Commensal bacteria are important regulators of antitumor immunity, and although the liver is exposed to gut bacteria, their role in antitumor surveillance of liver tumors is poorly understood. We found that altering commensal gut bacteria in mice induced a liver-selective antitumor effect, with an increase of hepatic CXCR6(+) natural killer T (NKT) cells and heightened interferon-gamma production upon antigen stimulation. In vivo functional studies showed that NKT cells mediated liver-selective tumor inhibition. NKT cell accumulation was regulated by CXCL16 expression of liver sinusoidal endothelial cells, which was controlled by gut microbiome-mediated primary-to-secondary bile acid conversion. Our study suggests a link between gut bacteria-controlled bile acid metabolism and liver antitumor immunosurveillance.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000433039800040
WOS关键词	KILLER T-CELLS ; INTESTINAL MICROBIOTA ; TUMOR SURVEILLANCE ; THERAPY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/198749
专题	地球科学资源环境科学气候变化
作者单位	1.NCI, Gastrointestinal Malignancy Sect, Thorac & Gastrointestinal Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA; 2.NCI, Vaccine Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 3.NCI, Lab Human Carcinogenesis, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 4.Univ Hosp RWTH Aachen, Inst Pathol, D-52074 Aachen, Germany; 5.Univ Hosp Heidelberg, Inst Pathol, D-69120 Heidelberg, Germany; 6.North Carolina State Univ, Coll Vet Med, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA; 7.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 8.NCI, Leidos Biomed Res Inc, Microbiome Sequencing Core, NIH, Bethesda, MD 20892 USA; 9.Chulabhorn Res Inst, Bangkok, Thailand; 10.NCI CCR Liver Canc Program, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Ma, Chi,Han, Miaojun,Heinrich, Bernd,et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells[J]. SCIENCE,2018,360(6391).
APA	Ma, Chi.,Han, Miaojun.,Heinrich, Bernd.,Fu, Qiong.,Zhang, Qianfei.,...&Greten, Tim F..(2018).Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.SCIENCE,360(6391).
MLA	Ma, Chi,et al."Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells".SCIENCE 360.6391(2018).