Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan5931 |
Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells | |
Ma, Chi1; Han, Miaojun1; Heinrich, Bernd1; Fu, Qiong1; Zhang, Qianfei1; Sandhu, Milan1; Agdashian, David1; Terabe, Masaki2; Berzofsky, Jay A.2; Fako, Valerie3; Ritz, Thomas4; Longerich, Thomas4,5; Theriot, Casey M.6; McCulloch, John A.7; Roy, Soumen7; Yuan, Wuxing7,8; Thovarai, Vishal7,8; Sen, Shurjo K.7,8; Ruchirawat, Mathuros9; Korangy, Firouzeh1; Wang, Xin Wei3,10; Trinchieri, Giorgio7; Greten, Tim F.1,10 | |
2018-05-25 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6391 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Thailand |
英文摘要 | Primary liver tumors and liver metastasis currently represent the leading cause of cancer-related death. Commensal bacteria are important regulators of antitumor immunity, and although the liver is exposed to gut bacteria, their role in antitumor surveillance of liver tumors is poorly understood. We found that altering commensal gut bacteria in mice induced a liver-selective antitumor effect, with an increase of hepatic CXCR6(+) natural killer T (NKT) cells and heightened interferon-gamma production upon antigen stimulation. In vivo functional studies showed that NKT cells mediated liver-selective tumor inhibition. NKT cell accumulation was regulated by CXCL16 expression of liver sinusoidal endothelial cells, which was controlled by gut microbiome-mediated primary-to-secondary bile acid conversion. Our study suggests a link between gut bacteria-controlled bile acid metabolism and liver antitumor immunosurveillance. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433039800040 |
WOS关键词 | KILLER T-CELLS ; INTESTINAL MICROBIOTA ; TUMOR SURVEILLANCE ; THERAPY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198749 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.NCI, Gastrointestinal Malignancy Sect, Thorac & Gastrointestinal Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA; 2.NCI, Vaccine Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 3.NCI, Lab Human Carcinogenesis, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 4.Univ Hosp RWTH Aachen, Inst Pathol, D-52074 Aachen, Germany; 5.Univ Hosp Heidelberg, Inst Pathol, D-69120 Heidelberg, Germany; 6.North Carolina State Univ, Coll Vet Med, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA; 7.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA; 8.NCI, Leidos Biomed Res Inc, Microbiome Sequencing Core, NIH, Bethesda, MD 20892 USA; 9.Chulabhorn Res Inst, Bangkok, Thailand; 10.NCI CCR Liver Canc Program, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Ma, Chi,Han, Miaojun,Heinrich, Bernd,et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells[J]. SCIENCE,2018,360(6391). |
APA | Ma, Chi.,Han, Miaojun.,Heinrich, Bernd.,Fu, Qiong.,Zhang, Qianfei.,...&Greten, Tim F..(2018).Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.SCIENCE,360(6391). |
MLA | Ma, Chi,et al."Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells".SCIENCE 360.6391(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论