Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaq0926 |
Gut microbiota utilize immunoglobulin A for mucosal colonization | |
Donaldson, G. P.1; Ladinsky, M. S.1; Yu, K. B.1; Sanders, J. G.2,3; Yoo, B. B.1; Chou, W. -C.4; Conner, M. E.5; Earl, A. M.4; Knight, R.2,3; Bjorkman, P. J.1; Mazmanian, S. K.1 | |
2018-05-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 360期号:6390页码:795-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The immune system responds vigorously to microbial infection while permitting lifelong colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the gut microbiota remain poorly described. We found that a regulatory system in the prominent human commensal Bacteroides fragilis modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. Specific immune recognition facilitated bacterial adherence to cultured intestinal epithelial cells and intimate association with the gut mucosal surface in vivo. The IgA response was required for B. fragilis (and other commensal species) to occupy a defined mucosal niche that mediates stable colonization of the gut through exclusion of exogenous competitors. Therefore, in addition to its role in pathogen clearance, we propose that IgA responses can be co-opted by the microbiome to engender robust host-microbial symbiosis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432473500050 |
WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; SECRETORY IGA ; BACTEROIDES-FRAGILIS ; SYMBIOTIC BACTERIA ; IN-VIVO ; IMMUNE ; HOMEOSTASIS ; ANTIBODIES ; SELECTION ; POLYSACCHARIDE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198699 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CALTECH, Dept Biol & Biol Engn, Pasadena, CA 91125 USA; 2.Univ Calif San Diego, Dept Pediat, San Diego, CA 92110 USA; 3.Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA; 4.Broad Inst MIT & Harvard, Infect Dis & Microbiome Program, Cambridge, MA 02142 USA; 5.Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Donaldson, G. P.,Ladinsky, M. S.,Yu, K. B.,et al. Gut microbiota utilize immunoglobulin A for mucosal colonization[J]. SCIENCE,2018,360(6390):795-+. |
APA | Donaldson, G. P..,Ladinsky, M. S..,Yu, K. B..,Sanders, J. G..,Yoo, B. B..,...&Mazmanian, S. K..(2018).Gut microbiota utilize immunoglobulin A for mucosal colonization.SCIENCE,360(6390),795-+. |
MLA | Donaldson, G. P.,et al."Gut microbiota utilize immunoglobulin A for mucosal colonization".SCIENCE 360.6390(2018):795-+. |
条目包含的文件 | 条目无相关文件。 |
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