Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar1954 |
Destabilizing mutations encode nongenetic variation that drives evolutionary innovation | |
Petrie, Katherine L.1,2; Palmer, Nathan D.1; Johnson, Daniel T.1; Medina, Sarah J.1; Yan, Stephanie J.1; Li, Victor1; Burmeister, Alita R.3; Meyer, Justin R.1 | |
2018-03-30 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6383页码:1542-1545 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan |
英文摘要 | Evolutionary innovations are often achieved by repurposing existing genes to perform new functions; however, the mechanisms enabling the transition from old to new remain controversial. We identified mutations in bacteriophage lambda's host-recognition gene J that confer enhanced adsorption to lambda's native receptor, LamB, and the ability to access a new receptor, OmpF. The mutations destabilize lambda particles and cause conformational bistability of J, which yields progeny of multiple phenotypic forms, each proficient at different receptors. This work provides an example of how nongenetic protein variation can catalyze an evolutionary innovation. We propose that cases where a single genotype canmanifest asmultiple phenotypes may bemore common than previously expected and offer a generalmechanism for evolutionary innovation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000428657000050 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198294 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif UC San Diego, Div Biol Sci, La Jolla, CA 92093 USA; 2.Tokyo Inst Technol, ELSI, Tokyo, Japan; 3.Yale Univ, Dept Ecol & Evolut, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Petrie, Katherine L.,Palmer, Nathan D.,Johnson, Daniel T.,et al. Destabilizing mutations encode nongenetic variation that drives evolutionary innovation[J]. SCIENCE,2018,359(6383):1542-1545. |
APA | Petrie, Katherine L..,Palmer, Nathan D..,Johnson, Daniel T..,Medina, Sarah J..,Yan, Stephanie J..,...&Meyer, Justin R..(2018).Destabilizing mutations encode nongenetic variation that drives evolutionary innovation.SCIENCE,359(6383),1542-1545. |
MLA | Petrie, Katherine L.,et al."Destabilizing mutations encode nongenetic variation that drives evolutionary innovation".SCIENCE 359.6383(2018):1542-1545. |
条目包含的文件 | 条目无相关文件。 |
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