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DOI | 10.1126/science.aan1053 |
Locally translated mTOR controls axonal local translation in nerve injury | |
Terenzio, Marco1; Koley, Sandip1; Samra, Nitzan1; Rishal, Ida1; Zhao, Qian2,6; Sahoo, Pabitra K.3; Urisman, Anatoly2; Marvaldi, Letizia1; Oses-Prieto, Juan A.2; Forester, Craig4; Gomes, Cynthia3,7; Kalinski, Ashley L.3,8; Di Pizio, Agostina1; Doron-Mandel, Ella1; Perry, Rotem Ben-Tov1; Koppel, Indrek1; Twiss, Jeffery L.3,5; Burlingame, Alma L.2; Fainzilber, Mike1 | |
2018-03-23 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6382页码:1416-1421 |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; USA; Peoples R China |
英文摘要 | How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured axons, owing to local translation of mTOR messenger RNA (mRNA). This mRNA was transported into axons by the cell size-regulating RNA-binding protein nucleolin. Furthermore, mTOR controlled local translation in injured axons. This included regulation of its own translation and that of retrograde injury signaling molecules such as importin beta 1 and STAT3 (signal transducer and activator of transcription 3). Deletion of the mTOR 3' untranslated region (3'UTR) in mice reduced mTOR in axons and decreased local translation after nerve injury. Both pharmacological inhibition of mTOR in axons and deletion of the mTOR 3'UTR decreased proprioceptive neuronal survival after nerve injury. Thus, mRNA localization enables spatiotemporal control of mTOR pathways regulating local translation and long-range intracellular signaling. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000428043600049 |
WOS关键词 | MESSENGER-RNA ; PROTEIN-SYNTHESIS ; REGENERATION ; LOCALIZATION ; GROWTH ; ACTIVATION ; NEURONS ; MODES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198250 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weizmann Inst Sci, Dept Biomol Sci, IL-76100 Rehovot, Israel; 2.Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA; 3.Univ South Carolina, Dept Biol Sci, Columbia, SC 29208 USA; 4.Univ Calif San Francisco, Div Pediat Allergy Immunol & Bone Marrow Transpla, San Francisco, CA 94158 USA; 5.Drexel Univ, Dept Neurobiol & Anat, Coll Med, Philadelphia, PA 19129 USA; 6.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China; 7.Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40202 USA; 8.Univ Michigan, Dept Cell & Dev Biol, Sch Med, 109 Zina Pitcher Pl, Ann Arbor, MI 48188 USA |
推荐引用方式 GB/T 7714 | Terenzio, Marco,Koley, Sandip,Samra, Nitzan,et al. Locally translated mTOR controls axonal local translation in nerve injury[J]. SCIENCE,2018,359(6382):1416-1421. |
APA | Terenzio, Marco.,Koley, Sandip.,Samra, Nitzan.,Rishal, Ida.,Zhao, Qian.,...&Fainzilber, Mike.(2018).Locally translated mTOR controls axonal local translation in nerve injury.SCIENCE,359(6382),1416-1421. |
MLA | Terenzio, Marco,et al."Locally translated mTOR controls axonal local translation in nerve injury".SCIENCE 359.6382(2018):1416-1421. |
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