Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aar4120 |
Systematic discovery of antiphage defense systems in the microbial pangenome | |
Doron, Shany; Melamed, Sarah; Ofir, Gal; Leavitt, Azita; Lopatina, Anna; Keren, Mai; Amitai, Gil; Sorek, Rotem | |
2018-03-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6379 |
文章类型 | Article |
语种 | 英语 |
英文摘要 | The arms race between bacteria and phages led to the development of sophisticated antiphage defense systems, including CRISPR-Cas and restriction-modification systems. Evidence suggests that known and unknown defense systems are located in "defense islands" in microbial genomes. Here, we comprehensively characterized the bacterial defensive arsenal by examining gene families that are clustered next to known defense genes in prokaryotic genomes. Candidate defense systems were systematically engineered and validated in model bacteria for their antiphage activities. We report nine previously unknown antiphage systems and one antiplasmid system that are widespread in microbes and strongly protect against foreign invaders. These include systems that adopted components of the bacterial flagella and condensin complexes. Our data also suggest a common, ancient ancestry of innate immunity components shared between animals, plants, and bacteria. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000435223400001 |
WOS关键词 | ESCHERICHIA-COLI ; PHAGE INFECTIONS ; PROTEIN FAMILIES ; DNA ; BACTERIA ; GENOMES ; RESTRICTION ; RESISTANCE ; PREDICTION ; EVOLUTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/198086 |
专题 | 地球科学 资源环境科学 气候变化 |
推荐引用方式 GB/T 7714 | Doron, Shany,Melamed, Sarah,Ofir, Gal,et al. Systematic discovery of antiphage defense systems in the microbial pangenome[J]. SCIENCE,2018,359(6379). |
APA | Doron, Shany.,Melamed, Sarah.,Ofir, Gal.,Leavitt, Azita.,Lopatina, Anna.,...&Sorek, Rotem.(2018).Systematic discovery of antiphage defense systems in the microbial pangenome.SCIENCE,359(6379). |
MLA | Doron, Shany,et al."Systematic discovery of antiphage defense systems in the microbial pangenome".SCIENCE 359.6379(2018). |
条目包含的文件 | 条目无相关文件。 |
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