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DOI | 10.1126/science.aao5056 |
Live imaging of neurogenesis in the adult mouse hippocampus | |
Pilz, Gregor-Alexander1,2; Bottes, Sara1,2; Betizeau, Marion1,2,3,4; Jorg, David J.5,6; Carta, Stefano1,2,8,9; Simons, Benjamin D.5,6,7; Helmchen, Fritjof8,9; Jessberger, Sebastian1,2 | |
2018-02-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6376页码:658-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; England |
英文摘要 | Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1) promoter undergo limited rounds of symmetric and asymmetric divisions, eliciting a burst of neurogenic activity, after which they are lost. Further, our data reveal unexpected asymmetric divisions of nonradial glia-like NSPCs. Cell fates of Ascl1-labeled lineages suggest a developmental-like program involving a sequential transition from a proliferative to a neurogenic phase. By providing a comprehensive description of lineage relationships, from dividing NSPCs to newborn neurons integrating into the hippocampal circuitry, our data offer insight into how NSPCs support life-long hippocampal neurogenesis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000425117700033 |
WOS关键词 | NEURAL STEM-CELLS ; ANALYSIS REVEALS ; DENTATE GYRUS ; NEURONS ; BEHAVIOR ; NICHE ; MULTIPOTENT ; HOMEOSTASIS ; MECHANISM ; NEOCORTEX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197950 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Zurich, Brain Res Inst, Fac Med, Lab Neural Plast, CH-8057 Zurich, Switzerland; 2.Univ Zurich, Brain Res Inst, Fac Sci, Lab Neural Plast, CH-8057 Zurich, Switzerland; 3.Univ Zurich, Inst Neuroinformat, CH-8057 Zurich, Switzerland; 4.Swiss Fed Inst Technol, CH-8057 Zurich, Switzerland; 5.Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England; 6.Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England; 7.Univ Cambridge, Wellcome Trust Med Res Council Cambridge Stem Cel, Cambridge CB2 1QR, England; 8.Univ Zurich, Lab Neural Circuit Dynam, Brain Res Inst, Fac Med, CH-8057 Zurich, Switzerland; 9.Univ Zurich, Lab Neural Circuit Dynam, Brain Res Inst, Fac Sci, CH-8057 Zurich, Switzerland |
推荐引用方式 GB/T 7714 | Pilz, Gregor-Alexander,Bottes, Sara,Betizeau, Marion,et al. Live imaging of neurogenesis in the adult mouse hippocampus[J]. SCIENCE,2018,359(6376):658-+. |
APA | Pilz, Gregor-Alexander.,Bottes, Sara.,Betizeau, Marion.,Jorg, David J..,Carta, Stefano.,...&Jessberger, Sebastian.(2018).Live imaging of neurogenesis in the adult mouse hippocampus.SCIENCE,359(6376),658-+. |
MLA | Pilz, Gregor-Alexander,et al."Live imaging of neurogenesis in the adult mouse hippocampus".SCIENCE 359.6376(2018):658-+. |
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