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DOI | 10.1126/science.aaq1144 |
Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics | |
Chen, Shuo1; Weitemier, Adam Z.1; Zeng, Xiao2; He, Linmeng1; Wang, Xiyu1; Tao, Yanqiu1; Huang, Arthur J. Y.1; Hashimotodani, Yuki3; Kano, Masanobu3,4; Iwasaki, Hirohide5; Parajuli, Laxmi Kumar5; Okabe, Shigeo5; Teh, Daniel B. Loong6; All, Angelo H.7; Tsutsui-Kimura, Iku8; Tanaka, Kenji F.8; Liu, Xiaogang2,9; McHugh, Thomas J.1,10 | |
2018-02-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2018 |
卷号 | 359期号:6376页码:679-683 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; Singapore; USA |
英文摘要 | Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000425117700039 |
WOS关键词 | EXCITATION ; NANOCRYSTALS ; THERANOSTICS ; INHIBITION ; DYNAMICS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197942 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.RIKEN Brain Sci Inst, Lab Circuit & Behav Physiol, Wako, Saitama 3510198, Japan; 2.Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore; 3.Univ Tokyo, Dept Neurophysiol, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; 4.Univ Tokyo, Int Res Ctr Neurointellegence WPI, Inst Adv Studies, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; 5.Univ Tokyo, Dept Cellular Neurobiol, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan; 6.Natl Univ Singapore, Singapore Inst Neurotechnol SINAPSE, Singapore 117456, Singapore; 7.Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA; 8.Keio Univ, Dept Neuropsychiatry, Sch Med, Tokyo 1608582, Japan; 9.Agcy Sci Technol & Res, Inst Mat Res & Engn, Singapore 117602, Singapore; 10.Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Tokyo, Japan |
推荐引用方式 GB/T 7714 | Chen, Shuo,Weitemier, Adam Z.,Zeng, Xiao,et al. Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics[J]. SCIENCE,2018,359(6376):679-683. |
APA | Chen, Shuo.,Weitemier, Adam Z..,Zeng, Xiao.,He, Linmeng.,Wang, Xiyu.,...&McHugh, Thomas J..(2018).Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.SCIENCE,359(6376),679-683. |
MLA | Chen, Shuo,et al."Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics".SCIENCE 359.6376(2018):679-683. |
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