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DOI | 10.1126/science.aal2052 |
Enzyme-free nucleic acid dynamical systems | |
Srinivas, Niranjan1; Parkin, James2; Seelig, Georg3,4; Winfree, Erik1,2,5; Soloveiehile, David6 | |
2017-12-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6369 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Chemistries exhibiting complex dynamics-from inorganic oscillators to gene regulatory networks-have been long known but either cannot be reprogrammed at will or rely on the sophisticated enzyme chemistry underlying the central dogma. Can simpler molecular mechanisms, designed from scratch, exhibit the same range of behaviors? Abstract chemical reaction networks have been proposed as a programming language for complex dynamics, along with their systematic implementation using short synthetic DNA molecules. We developed this technology for dynamical systems by identifying critical design principles and codifying them into a compiler automating the design process. Using this approach, we built an oscillator containing only DNA components, establishing that Watson-Crick base-pairing interactions alone suffice for complex chemical dynamics and that autonomous molecular systems can be designed via molecular programming languages. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417918500032 |
WOS关键词 | DNA STRAND DISPLACEMENT ; ESCHERICHIA-COLI ; CHEMICAL IMPLEMENTATION ; SELF-ORGANIZATION ; SEQUENCE DESIGN ; TOGGLE SWITCH ; KINETICS ; CELL ; COMPUTATION ; CONSTRUCTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197568 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA; 2.CALTECH, Bioengn, Pasadena, CA 91125 USA; 3.Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA; 4.Univ Washington, Paul G Allen Sch Comp Sci & Engn, Seattle, WA 98195 USA; 5.CALTECH, Comp Sci, Pasadena, CA 91125 USA; 6.Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78701 USA |
推荐引用方式 GB/T 7714 | Srinivas, Niranjan,Parkin, James,Seelig, Georg,et al. Enzyme-free nucleic acid dynamical systems[J]. SCIENCE,2017,358(6369). |
APA | Srinivas, Niranjan,Parkin, James,Seelig, Georg,Winfree, Erik,&Soloveiehile, David.(2017).Enzyme-free nucleic acid dynamical systems.SCIENCE,358(6369). |
MLA | Srinivas, Niranjan,et al."Enzyme-free nucleic acid dynamical systems".SCIENCE 358.6369(2017). |
条目包含的文件 | 条目无相关文件。 |
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