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DOI | 10.1126/science.aan0516 |
Potent peptidic fusion inhibitors of influenza virus | |
Kadam, Rameshwar U.1; Juraszek, Jarek2; Brandenburg, Boerries2,4; Buyck, Christophe3; Schepens, Wim B. G.3; Kesteleyn, Bart4; Stoops, Bart3; Vreeken, Rob J.3; Vermond, Jan2; Goutier, Wouter2; Tang, Chan2,4; Vogels, Ronald2,4; Friesen, Robert H. E.2,7; Goudsmit, Jaap2,5; van Dongen, Maria J. P.2,3; Wilson, Ian A.1,6 | |
2017-10-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6362页码:496-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands; Belgium |
英文摘要 | Influenza therapeutics with new targets and mechanisms of action are urgently needed to combat potential pandemics, emerging viruses, and constantly mutating strains in circulation. We report here on the design and structural characterization of potent peptidic inhibitors of influenza hemagglutinin. The peptide design was based on complementarity-determining region loops of human broadly neutralizing antibodies against the hemagglutinin (FI6v3 and CR9114). The optimized peptides exhibit nanomolar affinity and neutralization against influenza A group 1 viruses, including the 2009 H1N1 pandemic and avian H5N1 strains. The peptide inhibitors bind to the highly conserved stem epitope and block the low pH-induced conformational rearrangements associated with membrane fusion. These peptidic compounds and their advantageous biological properties should accelerate the development of new small molecule-and peptide-based therapeutics against influenza virus. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413757500039 |
WOS关键词 | MEMBRANE-FUSION ; A VIRUSES ; HEMAGGLUTININ ; ANTIBODY ; DESIGN ; REGION ; RECOGNITION ; OSELTAMIVIR ; PROTEINS ; INSIGHTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197205 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA; 2.Janssen Prevent Ctr, Leiden, Netherlands; 3.Janssen Res & Dev, Discovery Sci, Beerse, Belgium; 4.Janssen Infect Dis & Vaccines, Beerse, Belgium; 5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 6.Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA; 7.ProQR Therapeut, Leiden, Netherlands |
推荐引用方式 GB/T 7714 | Kadam, Rameshwar U.,Juraszek, Jarek,Brandenburg, Boerries,et al. Potent peptidic fusion inhibitors of influenza virus[J]. SCIENCE,2017,358(6362):496-+. |
APA | Kadam, Rameshwar U..,Juraszek, Jarek.,Brandenburg, Boerries.,Buyck, Christophe.,Schepens, Wim B. G..,...&Wilson, Ian A..(2017).Potent peptidic fusion inhibitors of influenza virus.SCIENCE,358(6362),496-+. |
MLA | Kadam, Rameshwar U.,et al."Potent peptidic fusion inhibitors of influenza virus".SCIENCE 358.6362(2017):496-+. |
条目包含的文件 | 条目无相关文件。 |
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