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DOI | 10.1126/science.aao2602 |
The microanatomic segregation of selection by apoptosis in the germinal center | |
Mayer, Christian T.1; Gazumyan, Anna1; Kara, Ervin E.1; Gitlin, Alexander D.1; Golijanin, Jovana1; Viant, Charlotte1; Pai, Joy1; Oliveira, Thiago Y.1; Wang, Qiao1; Escolano, Amelia1; Medina-Ramirez, Max2; Sanders, Rogier W.2,3; Nussenzweig, Michel C.1,4 | |
2017-10-13 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6360 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands |
英文摘要 | B cells undergo rapid cell division and affinity maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs). Homeostasis is maintained in part by B cell apoptosis. However, the precise contribution of apoptosis to GC biology and selection is not well defined. We developed apoptosis-indicator mice and used them to visualize, purify, and characterize dying GC B cells. Apoptosis is prevalent in the GC, with up to half of all GC B cells dying every 6 hours. Moreover, programmed cell death is differentially regulated in the light zone and the dark zone: Light-zone B cells die by default if they are not positively selected, whereas dark-zone cells die when their antigen receptors are damaged by activation-induced cytidine deaminase. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412841500040 |
WOS关键词 | PRIMARY IMMUNE-RESPONSE ; CYTIDINE DEAMINASE AID ; B-CELL LYMPHOMAS ; AFFINITY MATURATION ; IN-VIVO ; CLONAL SELECTION ; SELF-REACTIVITY ; C-MYC ; ANTIBODY ; MEMORY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197087 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA; 2.Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands; 3.Cornell Univ, Dept Microbiol & Immunol, Weill Med Coll, New York, NY 10065 USA; 4.Rockefeller Univ, HHMI, New York, NY 10065 USA |
推荐引用方式 GB/T 7714 | Mayer, Christian T.,Gazumyan, Anna,Kara, Ervin E.,et al. The microanatomic segregation of selection by apoptosis in the germinal center[J]. SCIENCE,2017,358(6360). |
APA | Mayer, Christian T..,Gazumyan, Anna.,Kara, Ervin E..,Gitlin, Alexander D..,Golijanin, Jovana.,...&Nussenzweig, Michel C..(2017).The microanatomic segregation of selection by apoptosis in the germinal center.SCIENCE,358(6360). |
MLA | Mayer, Christian T.,et al."The microanatomic segregation of selection by apoptosis in the germinal center".SCIENCE 358.6360(2017). |
条目包含的文件 | 条目无相关文件。 |
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