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DOI | 10.1126/science.aan4994 |
Gating of social reward by oxytocin in the ventral tegmental area | |
Hung, Lin W.1,2; Neuner, Sophie1; Polepalli, Jai S.1; Beier, Kevin T.1,3,4; Wright, Matthew3,5,6; Walsh, Jessica J.1; Lewis, Eastman M.7; Luo, Liqun3,4; Deisseroth, Karl3,5,6; Dolen, Gul7; Malenka, Robert C.1 | |
2017-09-29 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6358页码:1406-1411 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Australia |
英文摘要 | The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward circuitry, is necessary to elicit social reward. During social interactions, activity in paraventricular nucleus (PVN) OXT neurons increased. Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial behaviors. Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social interactions. OXT increased excitatory drive onto reward-specific VTA dopamine (DA) neurons. These results demonstrate that OXT promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411880800049 |
WOS关键词 | DOPAMINE NEURONS ; BEHAVIOR ; RECEPTOR ; MODELS ; AUTISM ; GENE ; MICE ; CUES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196970 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA; 2.Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia; 3.Stanford Univ, Howard Hughes Med Inst, Stanford, CA USA; 4.Stanford Univ, Dept Biol, Stanford, CA USA; 5.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 6.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA; 7.Johns Hopkins Univ, Dept Neurosci, Baltimore, MD USA |
推荐引用方式 GB/T 7714 | Hung, Lin W.,Neuner, Sophie,Polepalli, Jai S.,et al. Gating of social reward by oxytocin in the ventral tegmental area[J]. SCIENCE,2017,357(6358):1406-1411. |
APA | Hung, Lin W..,Neuner, Sophie.,Polepalli, Jai S..,Beier, Kevin T..,Wright, Matthew.,...&Malenka, Robert C..(2017).Gating of social reward by oxytocin in the ventral tegmental area.SCIENCE,357(6358),1406-1411. |
MLA | Hung, Lin W.,et al."Gating of social reward by oxytocin in the ventral tegmental area".SCIENCE 357.6358(2017):1406-1411. |
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