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DOI | 10.1126/science.aal4677 |
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine | |
Bel, Shai1; Pendse, Mihir1; Wang, Yuhao1; Li, Yun1; Ruhn, Kelly A.1; Hassell, Brian1; Leal, Tess1; Winter, Sebastian E.2; Xavier, Ramnik J.3,4,5,6; Hooper, Lora V.1,7 | |
2017-09-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6355页码:1047-1051 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Intestinal Paneth cells limit bacterial invasion by secreting antimicrobial proteins, including lysozyme. However, invasive pathogens can disrupt the Golgi apparatus, interfering with secretion and compromising intestinal antimicrobial defense. Here we show that during bacterial infection, lysozyme is rerouted via secretory autophagy, an autophagy-based alternative secretion pathway. Secretory autophagy was triggered in Paneth cells by bacteria-induced endoplasmic reticulum (ER) stress, required extrinsic signals from innate lymphoid cells, and limited bacterial dissemination. Secretory autophagy was disrupted in Paneth cells of mice harboring a mutation in autophagy gene Atg16L1 that confers increased risk for Crohn's disease in humans. Our findings identify a role for secretory autophagy in intestinal defense and suggest why Crohn's disease is associated with genetic mutations that affect both the ER stress response and autophagy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000409455700047 |
WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; LINKS ER STRESS ; GENE ATG16L1 ; DEFENSE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196827 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75390 USA; 2.Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA; 3.Broad Inst, Cambridge, MA 02142 USA; 4.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA; 5.Harvard Med Sch, Gastrointestinal Unit, Boston, MA 02142 USA; 6.Harvard Med Sch, Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02142 USA; 7.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA |
推荐引用方式 GB/T 7714 | Bel, Shai,Pendse, Mihir,Wang, Yuhao,et al. Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine[J]. SCIENCE,2017,357(6355):1047-1051. |
APA | Bel, Shai.,Pendse, Mihir.,Wang, Yuhao.,Li, Yun.,Ruhn, Kelly A..,...&Hooper, Lora V..(2017).Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.SCIENCE,357(6355),1047-1051. |
MLA | Bel, Shai,et al."Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine".SCIENCE 357.6355(2017):1047-1051. |
条目包含的文件 | 条目无相关文件。 |
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