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DOI | 10.1126/science.aan6349 |
An algal photoenzyme converts fatty acids to hydrocarbons | |
Sorigue, Damien1,2; Legeret, Bertrand1,2; Cuine, Stephan1,2; Blangy, Stephanie1,2; Moulin, Solene1,2; Billon, Emmanuelle1,2; Richaud, Pierre1,2; Brugiere, Sabine3,4; Coute, Yohann3,4; Nurizzo, Didier5; Mueller, Pavel6; Brettel, Klaus6; Pignol, David7,8; Arnoux, Pascal7,8; Li-Beisson, Yonghua1,2; Peltier, Gilles1,2; Beisson, Fred1,2 | |
2017-09-01 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6354页码:903-907 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Although many organisms capture or respond to sunlight, few enzymes are known to be driven by light. Among these are DNA photolyases and the photosynthetic reaction centers. Here, we show that the microalga Chlorella variabilis NC64A harbors a photoenzyme that acts in lipid metabolism. This enzyme belongs to an algae-specific clade of the glucose-methanol-choline oxidoreductase family and catalyzes the decarboxylation of free fatty acids to n-alkanes or -alkenes in response to blue light. Crystal structure of the protein reveals a fatty acid-binding site in a hydrophobic tunnel leading to the light-capturing flavin adenine dinucleotide ( FAD) cofactor. The decarboxylation is initiated through electron abstraction from the fatty acid by the photoexcited FAD with a quantum yield >80%. This photoenzyme, which we name fatty acid photodecarboxylase, may be useful in light-driven, bio-based production of hydrocarbons. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408734900039 |
WOS关键词 | MICROBIAL BIOSYNTHESIS ; DNA-REPAIR ; LIGHT ; MECHANISMS ; PHOTORECEPTORS ; PROTEINS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196766 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Commissariat Energie Atom & Energies Alternat CEA, CNRS, Biosci & Biotechnol Inst Aix Marseille BIAM, F-13108 St Paul Les Durance, France; 2.Aix Marseille Univ, UMR 7265 LB3M, CEA Cadarache, F-13108 St Paul Les Durance, France; 3.Univ Grenoble Alpes, CEA, F-38000 Grenoble, France; 4.INSERM, BIG BGE, F-38000 Grenoble, France; 5.European Synchrotron Radiat Facil, 71 Ave Martyrs,CS 40220, F-38043 Grenoble, France; 6.Univ Paris Saclay, Univ Paris Sud, CNRS, CEA,I2BC, F-91198 Gif Sur Yvette, France; 7.CEA, CNRS, BIAM, F-13108 St Paul Les Durance, France; 8.Aix Marseille Univ, UMR LBC 7265, CEA Cadarache, F-13108 St Paul Les Durance, France |
推荐引用方式 GB/T 7714 | Sorigue, Damien,Legeret, Bertrand,Cuine, Stephan,et al. An algal photoenzyme converts fatty acids to hydrocarbons[J]. SCIENCE,2017,357(6354):903-907. |
APA | Sorigue, Damien.,Legeret, Bertrand.,Cuine, Stephan.,Blangy, Stephanie.,Moulin, Solene.,...&Beisson, Fred.(2017).An algal photoenzyme converts fatty acids to hydrocarbons.SCIENCE,357(6354),903-907. |
MLA | Sorigue, Damien,et al."An algal photoenzyme converts fatty acids to hydrocarbons".SCIENCE 357.6354(2017):903-907. |
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