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DOI | 10.1126/science.aam6607 |
ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice | |
Ho, Lena1; van Dijk, Marie2; Chye, Sam Tan Jian1; Messerschmidt, Daniel M.3; Chng, Serene C.1; Ong, Sheena1; Yi, Ling Ka3; Boussata, Souad2; Goh, Grace Hui-Yi1; Afink, Gijs B.2; Lim, Chin Yan1; Dunn, N. Ray1; Solter, Davor1; Knowles, Barbara B.1; Reversade, Bruno1,2,3,4,5 | |
2017-08-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6352页码:707-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Singapore; Netherlands; Turkey |
英文摘要 | Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin receptor (APLNR, or APJ), is a circulating hormone secreted by the placenta. Elabela but not Apelin knockout pregnant mice exhibit PE-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis. In mice, infusion of exogenous ELA normalizes hypertension, proteinuria, and birth weight. ELA, which is abundant in human placentas, increases the invasiveness of trophoblast-like cells, suggesting that it enhances placental development to prevent PE. The ELA-APLNR signaling axis may offer a new paradigm for the treatment of common pregnancy-related complications, including PE. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000407793600040 |
WOS关键词 | GROWTH-FACTOR ; EXPRESSION ; RECEPTOR ; TISSUE ; CELLS ; APJ |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196696 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.ASTAR, Inst Med Biol, 8A Biomed Grove, Singapore 138648, Singapore; 2.Acad Med Ctr, Reprod Biol Lab, Obstet & Gynaecol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; 3.ASTAR, Inst Mol & Cell Biol, 61 Biopolis Dr, Singapore 138673, Singapore; 4.Natl Univ Singapore, Dept Paediat, 1E Kent Ridge Rd, Singapore 119228, Singapore; 5.Koc Univ, Med Genet Dept, Sch Med, TR-34010 Istanbul, Turkey |
推荐引用方式 GB/T 7714 | Ho, Lena,van Dijk, Marie,Chye, Sam Tan Jian,et al. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice[J]. SCIENCE,2017,357(6352):707-+. |
APA | Ho, Lena.,van Dijk, Marie.,Chye, Sam Tan Jian.,Messerschmidt, Daniel M..,Chng, Serene C..,...&Reversade, Bruno.(2017).ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.SCIENCE,357(6352),707-+. |
MLA | Ho, Lena,et al."ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice".SCIENCE 357.6352(2017):707-+. |
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