Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aam9710 |
Deriving genomic diagnoses without revealing patient genomes | |
Jagadeesh, Karthik A.1; Wu, David J.1; Birgmeier, Johannes A.1; Boneh, Dan1,2; Bejerano, Gill1,3,4 | |
2017-08-18 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6352页码:692-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Patient genomes are interpretable only in the context of other genomes; however, genome sharing enables discrimination. Thousands of monogenic diseases have yielded definitive genomic diagnoses and potential gene therapy targets. Here we show how to provide such diagnoses while preserving participant privacy through the use of secure multiparty computation. In multiple real scenarios (small patient cohorts, trio analysis, two-hospital collaboration), we used our methods to identify the causal variant and discover previously unrecognized disease genes and variants while keeping up to 99.7% of all participants' most sensitive genomic information private. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000407793600036 |
WOS关键词 | MUTATIONS ; ENCRYPTION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196693 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA; 3.Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA; 4.Stanford Univ, Dept Pediat, Div Med Genet, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Jagadeesh, Karthik A.,Wu, David J.,Birgmeier, Johannes A.,et al. Deriving genomic diagnoses without revealing patient genomes[J]. SCIENCE,2017,357(6352):692-+. |
APA | Jagadeesh, Karthik A.,Wu, David J.,Birgmeier, Johannes A.,Boneh, Dan,&Bejerano, Gill.(2017).Deriving genomic diagnoses without revealing patient genomes.SCIENCE,357(6352),692-+. |
MLA | Jagadeesh, Karthik A.,et al."Deriving genomic diagnoses without revealing patient genomes".SCIENCE 357.6352(2017):692-+. |
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