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DOI | 10.1126/science.aam5339 |
Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition | |
Zenk, Fides1,2; Loeser, Eva1; Schiavo, Rosaria1; Kilpert, Fabian3; Bogdanovic, Ozren4,5,6; Iovino, Nicola1 | |
2017-07-14 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6347页码:212-216 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Australia |
英文摘要 | Gametes carry parental genetic material to the next generation. Stress-induced epigenetic changes in the germ line can be inherited and can have a profound impact on offspring development. However, the molecular mechanisms and consequences of transgenerational epigenetic inheritance are poorly understood. We found that Drosophila oocytes transmit the repressive histone mark H3K27me3 to their offspring. Maternal contribution of the histone methyltransferase Enhancer of zeste, the enzymatic component of Polycomb repressive complex 2, is required for active propagation of H3K27me3 during early embryogenesis. H3K27me3 in the early embryo prevents aberrant accumulation of the active histone mark H3K27ac at regulatory regions and precocious activation of lineage-specific genes at zygotic genome activation. Disruption of the germ line-inherited Polycomb epigenetic memory causes embryonic lethality that cannot be rescued by late zygotic reestablishment of H3K27me3. Thus, maternally inherited H3K27me3, propagated in the early embryo, regulates the activation of enhancers and lineage-specific genes during development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405391700049 |
WOS关键词 | DROSOPHILA-MELANOGASTER ; CHROMATIN STATE ; GENE-EXPRESSION ; IN-VIVO ; POLYCOMB ; MECHANISMS ; REPRESSION ; MAMMALS ; MEMORY ; DNA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196461 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Immunobiol & Epigenet, Dept Chromatin Regulat, D-79108 Freiburg, Germany; 2.Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany; 3.Max Planck Inst Immunobiol & Epigenet, Bioinformat Facil, D-79108 Freiburg, Germany; 4.Garvan Inst Med Res, Genom & Epigenet Div, Sydney, NSW, Australia; 5.Univ New South Wales, St Vincents Clin Sch, Fac Med, Sydney, NSW, Australia; 6.Univ Western Australia, ARC Ctr Excellence Plant Energy Biol, Perth, WA 6009, Australia |
推荐引用方式 GB/T 7714 | Zenk, Fides,Loeser, Eva,Schiavo, Rosaria,et al. Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition[J]. SCIENCE,2017,357(6347):212-216. |
APA | Zenk, Fides,Loeser, Eva,Schiavo, Rosaria,Kilpert, Fabian,Bogdanovic, Ozren,&Iovino, Nicola.(2017).Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition.SCIENCE,357(6347),212-216. |
MLA | Zenk, Fides,et al."Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition".SCIENCE 357.6347(2017):212-216. |
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