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DOI | 10.1126/science.aal3839 |
Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis | |
Paul, Alex1,2; Chaker, Zayna3; Doetsch, Fiona2,3 | |
2017-06-30 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6345页码:1383-1385 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Switzerland |
英文摘要 | Neural stem cells (NSCs) in specialized niches in the adult mammalian brain generate neurons throughout life. NSCs in the adult mouse ventricular-subventricular zone (V-SVZ) exhibit a regional identity and, depending on their location, generate distinct olfactory bulb interneuron subtypes. Here, we show that the hypothalamus, a brain area regulating physiological states, provides long-range regionalized input to the V-SVZ niche and can regulate specific NSC subpopulations. Hypothalamic proopiomelanocortin neurons selectively innervate the anterior ventral V-SVZ and promote the proliferation of Nkx2.1(+) NSCs and the generation of deep granule neurons. Accordingly, hunger and satiety regulate adult neurogenesis by modulating the activity of this hypothalamic-V-SVZ connection. Our findings reveal that neural circuitry, via mosaic innervation of the V-SVZ, can recruit distinct NSC pools, allowing on-demand neurogenesis in response to physiology and environmental signals. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000404351500037 |
WOS关键词 | SUBVENTRICULAR ZONE ; TRANSGENIC MICE ; NEURONS ; NICHE ; PROTEIN ; IDENTIFICATION ; ASTROCYTES ; RECEPTORS ; BRAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196367 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA; 2.Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA; 3.Univ Basel, Biozentrum, CH-4056 Basel, Switzerland |
推荐引用方式 GB/T 7714 | Paul, Alex,Chaker, Zayna,Doetsch, Fiona. Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis[J]. SCIENCE,2017,356(6345):1383-1385. |
APA | Paul, Alex,Chaker, Zayna,&Doetsch, Fiona.(2017).Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis.SCIENCE,356(6345),1383-1385. |
MLA | Paul, Alex,et al."Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis".SCIENCE 356.6345(2017):1383-1385. |
条目包含的文件 | 条目无相关文件。 |
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