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DOI | 10.1126/science.aai7407 |
Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila | |
Corson, Francis1; Couturier, Lydie2,3; Rouault, Herve2,3,4; Mazouni, Khalil2,3; Schweisguth, Francois2,3 | |
2017-05-05 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6337 |
文章类型 | Article |
语种 | 英语 |
国家 | France; USA |
英文摘要 | The emergence of spatial patterns in developing multicellular organisms relies on positional cues and cell-cell communication. Drosophila sensory organs have informed a paradigm in which these operate in two distinct steps: Prepattern factors drive localized proneural activity, then Notch-mediated lateral inhibition singles out neural precursors. Here we show that self-organization through Notch signaling also establishes the proneural stripes that resolve into rows of sensory bristles on the fly thorax. Patterning, initiated by a gradient of Delta ligand expression, progresses through inhibitory signaling between and within stripes. Thus, Notch signaling can support self-organized tissue patterning as a prepattern is transduced by cell-cell interactions into a refined arrangement of cellular fates. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400545700028 |
WOS关键词 | LATERAL INHIBITION ; CELL FATE ; INNER-EAR ; NEURALIZED ENCODES ; BRISTLE PATTERNS ; DELTA ; MECHANISM ; PRECURSORS ; GENES ; MELANOGASTER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195987 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Paris 06, Univ Paris Diderot, CNRS, Lab Phys Stat,Ecole Normale Super, F-75005 Paris, France; 2.Inst Pasteur, Dept Dev & Stem Cell Biol, F-75015 Paris, France; 3.CNRS, UMR3738, F-75015 Paris, France; 4.Howard Hughes Med Inst, Ashburn, VA 20147 USA |
推荐引用方式 GB/T 7714 | Corson, Francis,Couturier, Lydie,Rouault, Herve,et al. Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila[J]. SCIENCE,2017,356(6337). |
APA | Corson, Francis,Couturier, Lydie,Rouault, Herve,Mazouni, Khalil,&Schweisguth, Francois.(2017).Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila.SCIENCE,356(6337). |
MLA | Corson, Francis,et al."Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila".SCIENCE 356.6337(2017). |
条目包含的文件 | 条目无相关文件。 |
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