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DOI | 10.1126/science.aai8764 |
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation | |
Xu, Zhenjie1,2,6; Schaedel, Laura3; Portran, Didier1; Aguilar, Andrea1; Gaillard, Jeremie3; Marinkovich, M. Peter2,4; Thery, Manuel3,5; Nachury, Maxence V.1 | |
2017-04-21 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6335页码:328-332 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France |
英文摘要 | Eukaryotic cells rely on long-lived microtubules for intracellular transport and as compression-bearing elements. We considered that long-lived microtubules are acetylated inside their lumen and that microtubule acetylation may modify microtubule mechanics. Here, we found that tubulin acetylation is required for the mechanical stabilization of long-lived microtubules in cells. Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage. Nocodazole-resistant microtubules lost upon removal of acetylation were largely restored by either pharmacological or physical removal of compressive forces. In in vitro reconstitution experiments, acetylation was sufficient to protect microtubules from mechanical breakage. Thus, acetylation increases mechanical resilience to ensure the persistence of long-lived microtubules. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399540100064 |
WOS关键词 | ALPHA-TUBULIN ; SELF-REPAIR ; CELLS ; CYTOSKELETON ; FLEXIBILITY ; INSTABILITY ; ADHESIONS ; DYNAMICS ; POLARITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195864 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Mol & Cellular Physiol, Sch Med, Stanford, CA 94305 USA; 2.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA; 3.Univ Grenoble Alpes, CEA, Biosci & Biotechnol Inst Grenoble, CytoMorpho Lab,LPCV,UMR 5168,INRA,CNRS, 17 Rue Martyrs, F-38054 Grenoble, France; 4.Palo Alto Vet Affairs Med Ctr, Div Dermatol, Palo Alto, CA 94305 USA; 5.Univ Paris Diderot, Hop St Louis, AP HP, CytoMorpho Lab,A2T,UMRS 1160,Inst Univ Hematol,IN, 1 Ave Claude Vellefaux, F-75010 Paris, France; 6.Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Xu, Zhenjie,Schaedel, Laura,Portran, Didier,et al. Microtubules acquire resistance from mechanical breakage through intralumenal acetylation[J]. SCIENCE,2017,356(6335):328-332. |
APA | Xu, Zhenjie.,Schaedel, Laura.,Portran, Didier.,Aguilar, Andrea.,Gaillard, Jeremie.,...&Nachury, Maxence V..(2017).Microtubules acquire resistance from mechanical breakage through intralumenal acetylation.SCIENCE,356(6335),328-332. |
MLA | Xu, Zhenjie,et al."Microtubules acquire resistance from mechanical breakage through intralumenal acetylation".SCIENCE 356.6335(2017):328-332. |
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