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DOI | 10.1126/science.aai7984 |
Breathing control center neurons that promote arousal in mice | |
Yackle, Kevin1,6; Schwarz, Lindsay A.2,7; Kam, Kaiwen3,4; Sorokin, Jordan M.5; Huguenard, John R.5; Feldman, Jack L.3; Luo, Liqun2; Krasnow, Mark A.1 | |
2017-03-31 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6332页码:1411-1415 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Slow, controlled breathing has been used for centuries to promote mental calming, and it is used clinically to suppress excessive arousal such as panic attacks. However, the physiological and neural basis of the relationship between breathing and higher-order brain activity is unknown. We found a neuronal subpopulation in the mouse preBotzinger complex (preBotC), the primary breathing rhythm generator, which regulates the balance between calm and arousal behaviors. Conditional, bilateral genetic ablation of the similar to 175 Cdh9/Dbx1 double-positive preBotC neurons in adult mice left breathing intact but increased calm behaviors and decreased time in aroused states. These neurons project to, synapse on, and positively regulate noradrenergic neurons in the locus coeruleus, a brain center implicated in attention, arousal, and panic that projects throughout the brain. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397809500040 |
WOS关键词 | COERULEUS-NORADRENERGIC SYSTEM ; PRE-BOTZINGER COMPLEX ; PREBOTZINGER COMPLEX ; RESPIRATORY NEURONS ; PANIC DISORDER ; SPINAL-CORD ; MODULATION ; RHYTHM ; ANXIETY ; STRESS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195731 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Biochem, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA; 2.Stanford Univ, Howard Hughes Med Inst, Dept Biol, Stanford, CA 94305 USA; 3.Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Syst Neurobiol Lab, Los Angeles, CA 90095 USA; 4.Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Cell Biol & Anat, N Chicago, IL 60064 USA; 5.Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA; 6.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA; 7.St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N Lauderdale St, Memphis, TN 38105 USA |
推荐引用方式 GB/T 7714 | Yackle, Kevin,Schwarz, Lindsay A.,Kam, Kaiwen,et al. Breathing control center neurons that promote arousal in mice[J]. SCIENCE,2017,355(6332):1411-1415. |
APA | Yackle, Kevin.,Schwarz, Lindsay A..,Kam, Kaiwen.,Sorokin, Jordan M..,Huguenard, John R..,...&Krasnow, Mark A..(2017).Breathing control center neurons that promote arousal in mice.SCIENCE,355(6332),1411-1415. |
MLA | Yackle, Kevin,et al."Breathing control center neurons that promote arousal in mice".SCIENCE 355.6332(2017):1411-1415. |
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