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DOI | 10.1126/science.aah6317 |
Mechanisms for initiating cellular DNA replication | |
Bleichert, Franziska1,3; Botchan, Michael R.2; Berger, James M.1 | |
2017-02-24 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6327 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; Switzerland |
英文摘要 | Cellular DNA replication factories depend on ring-shaped hexameric helicases to aid DNA synthesis by processively unzipping the parental DNA helix. Replicative helicases are loaded onto DNA by dedicated initiator, loader, and accessory proteins during the initiation of DNA replication in a tightly regulated, multistep process. We discuss here themolecular choreography of DNA replication initiation across the three domains of life, highlighting similarities and differences in the strategies used to deposit replicative helicases onto DNA and to melt the DNA helix in preparation for replisome assembly. Although initiators and loaders are phylogenetically related, the mechanisms they use for accomplishing similar tasks have diverged considerably and in an unpredictable manner. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395127600032 |
WOS关键词 | ORIGIN RECOGNITION COMPLEX ; MEIER-GORLIN SYNDROME ; MINICHROMOSOME MAINTENANCE PROTEIN ; SINGLE-STRANDED-DNA ; NUCLEIC-ACID TRANSLOCASES ; ESCHERICHIA-COLI ; STRUCTURAL BASIS ; IN-VITRO ; METHANOBACTERIUM-THERMOAUTOTROPHICUM ; FUNCTIONAL-ANALYSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195499 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA; 2.Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA; 3.Friedrich Miescher Inst Biomed Res, Basel, Switzerland |
推荐引用方式 GB/T 7714 | Bleichert, Franziska,Botchan, Michael R.,Berger, James M.. Mechanisms for initiating cellular DNA replication[J]. SCIENCE,2017,355(6327). |
APA | Bleichert, Franziska,Botchan, Michael R.,&Berger, James M..(2017).Mechanisms for initiating cellular DNA replication.SCIENCE,355(6327). |
MLA | Bleichert, Franziska,et al."Mechanisms for initiating cellular DNA replication".SCIENCE 355.6327(2017). |
条目包含的文件 | 条目无相关文件。 |
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