Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aai8982 |
Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus | |
Wang, Xindan1,5; Brandao, Hugo B.2; Le, Tung B. K.3,6; Laub, Michael T.3,4; Rudner, David Z.1 | |
2017-02-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6324页码:524-527 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; England |
英文摘要 | Structural maintenance of chromosomes (SMC) complexes play critical roles in chromosome dynamics in virtually all organisms, but how they function remains poorly understood. In the bacterium Bacillus subtilis, SMC-condensin complexes are topologically loaded at centromeric sites adjacent to the replication origin. Here we provide evidence that these ring-shaped assemblies tether the left and right chromosome arms together while traveling from the origin to the terminus (>2 megabases) at rates >50 kilobases per minute. Condensin movement scales linearly with time, providing evidence for an active transport mechanism. These data support a model in which SMC complexes function by processively enlarging DNA loops. Loop formation followed by processive enlargement provides a mechanism by which condensin complexes compact and resolve sister chromatids in mitosis and by which cohesin generates topologically associating domains during interphase. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393183100045 |
WOS关键词 | BACTERIAL CHROMOSOME ; B. SUBTILIS ; CONDENSIN ; DNA ; ORGANIZATION ; REPLICATION ; SEGREGATION ; PROMOTES ; GENOME ; ARCHITECTURE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195358 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Dept Microbiol & Immunobiol, 77 Ave Louis Pasteur, Boston, MA 02115 USA; 2.Harvard Univ, Grad Program Biophys, Cambridge, MA 02138 USA; 3.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 4.MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA; 5.Indiana Univ, Dept Biol, Bloomington, IN 47405 USA; 6.John Innes Ctr, Dept Mol Microbiol, Norwich NR4 7UH, Norfolk, England |
推荐引用方式 GB/T 7714 | Wang, Xindan,Brandao, Hugo B.,Le, Tung B. K.,et al. Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus[J]. SCIENCE,2017,355(6324):524-527. |
APA | Wang, Xindan,Brandao, Hugo B.,Le, Tung B. K.,Laub, Michael T.,&Rudner, David Z..(2017).Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus.SCIENCE,355(6324),524-527. |
MLA | Wang, Xindan,et al."Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus".SCIENCE 355.6324(2017):524-527. |
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