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DOI | 10.1126/science.aaf8399 |
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy | |
Davoli, Teresa1; Uno, Hajime2; Wooten, Eric C.1; Elledge, Stephen J.1 | |
2017-01-20 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6322 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Immunotherapies based on immune checkpoint blockade are highly effective in a subset of patients. An ongoing challenge is the identification of biomarkers that predict which patients will benefit from these therapies. Aneuploidy, also known as somatic copy number alterations (SCNAs), is widespread in cancer and is posited to drive tumorigenesis. Analyzing 12 human cancer types, we find that, for most, highly aneuploid tumors show reduced expression of markers of cytotoxic infiltrating immune cells, especially CD8(+) T cells, and increased expression of cell proliferation markers. Different types of SCNAs predict the proliferation and immune signatures, implying distinct underlying mechanisms. Using published data from two clinical trials of immune checkpoint blockade therapy for metastatic melanoma, we found that tumor aneuploidy inversely correlates with patient survival. Together with other tumor characteristics such as tumor mutational load, aneuploidy may thus help identify patients most likely to respond to immunotherapy. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392204800028 |
WOS关键词 | COPY-NUMBER ALTERATION ; DIFFERENTIAL EXPRESSION ANALYSIS ; ONCOGENE-INDUCED SENESCENCE ; NEGATIVE BREAST-CANCER ; DNA-DAMAGE RESPONSE ; CELL LUNG-CANCER ; GENE-EXPRESSION ; GENOMIC INSTABILITY ; CHROMOSOMAL INSTABILITY ; CTLA-4 BLOCKADE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195270 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Div Genet, Brigham & Womens Hosp, Howard Hughes Med Inst,Dept Genet, Boston, MA 02115 USA; 2.Dana Farber Canc Inst, Boston, MA 02215 USA |
推荐引用方式 GB/T 7714 | Davoli, Teresa,Uno, Hajime,Wooten, Eric C.,et al. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy[J]. SCIENCE,2017,355(6322). |
APA | Davoli, Teresa,Uno, Hajime,Wooten, Eric C.,&Elledge, Stephen J..(2017).Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.SCIENCE,355(6322). |
MLA | Davoli, Teresa,et al."Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy".SCIENCE 355.6322(2017). |
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