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Impact of Dust on climate and AMOC during the Last Glacial Maximum Simulated by CESM1.2 期刊论文
Geophysical Research Letters, 2022
作者:  Ming Zhang;  Yonggang Liu;  Jiang Zhu;  Zhuoqun Wang;  Zhengyu Liu
收藏  |  浏览/下载:10/0  |  提交时间:2022/02/16
Senolytics reduce coronavirus-related mortality in old mice 期刊论文
Science, 2021
作者:  Christina D. Camell;  Matthew J. Yousefzadeh;  Yi Zhu;  Larissa G. P. Langhi Prata;  Matthew A. Huggins;  Mark Pierson;  Lei Zhang;  Ryan D. O’Kelly;  Tamar Pirtskhalava;  Pengcheng Xun;  Keisuke Ejima;  Ailing Xue;  Utkarsh Tripathi;  Jair Machado Espindola-Netto;  Nino Giorgadze;  Elizabeth J. Atkinson;  Christina L. Inman;  Kurt O. Johnson;  Stephanie H. Cholensky;  Timothy W. Carlson;  Nathan K. LeBrasseur;  Sundeep Khosla;  M. Gerard O’Sullivan;  David B. Allison;  Stephen C. Jameson;  Alexander Meves;  Ming Li;  Y. S. Prakash;  Sergio E. Chiarella;  Sara E. Hamilton;  Tamara Tchkonia;  Laura J. Niedernhofer;  James L. Kirkland;  Paul D. Robbins
收藏  |  浏览/下载:14/0  |  提交时间:2021/07/27
Quantum walks on a programmable two-dimensional 62-qubit superconducting processor 期刊论文
Science, 2021
作者:  Ming Gong;  Shiyu Wang;  Chen Zha;  Ming-Cheng Chen;  He-Liang Huang;  Yulin Wu;  Qingling Zhu;  Youwei Zhao;  Shaowei Li;  Shaojun Guo;  Haoran Qian;  Yangsen Ye;  Fusheng Chen;  Chong Ying;  Jiale Yu;  Daojin Fan;  Dachao Wu;  Hong Su;  Hui Deng;  Hao Rong;  Kaili Zhang;  Sirui Cao;  Jin Lin;  Yu Xu;  Lihua Sun;  Cheng Guo;  Na Li;  Futian Liang;  V. M. Bastidas;  Kae Nemoto;  W. J. Munro;  Yong-Heng Huo;  Chao-Yang Lu;  Cheng-Zhi Peng;  Xiaobo Zhu;  Jian-Wei Pan
收藏  |  浏览/下载:16/0  |  提交时间:2021/06/07
Nation wide increase of polycyclic aromatic hydrocarbons in ultrafine particles during winter over China 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Qingqing Yu, Xiang Ding, Quanfu He, Weiqiang Yang, Ming Zhu, Sheng Li, Runqi Zhang, Ruqin Shen, Yanli Zhang, Xinhui Bi, Yuesi Wang, Ping’an Peng, and Xinming Wang
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/29
DNA-directed nanofabrication of high-performance carbon nanotube field-effect transistors 期刊论文
Science, 2020
作者:  Mengyu Zhao;  Yahong Chen;  Kexin Wang;  Zhaoxuan Zhang;  Jason K. Streit;  Jeffrey A. Fagan;  Jianshi Tang;  Ming Zheng;  Chaoyong Yang;  Zhi Zhu;  Wei Sun
收藏  |  浏览/下载:7/0  |  提交时间:2020/05/25
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载:15/0  |  提交时间:2020/05/20
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
A preliminary study on wind tunnel simulations of the explosive growth and dissipation of fine particulate matter in ambient air 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Xu, Jingxin;  Zhu, Fahua;  Wang, Sheng;  Zhao, Xiuyong;  Zhang, Ming;  Ge, Xinlei;  Wang, Junfeng;  Tian, Wenxin;  Wang, Liwen;  Yang, Liu;  Ding, Li;  Lu, Xiaobo;  Chen, Xinxin;  Zheng, Youfei;  Guo, Zhaobing
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Wind tunnel  Fine particulate matter  Explosive growth  Dissipation  Relative humidity  Liquid water content  
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03