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Linear vs. nonlinear (convex and concave) hedging rules for reservoir optimization operation 期刊论文
Water Resources Research, 2021
作者:  Xiang Zeng;  Jay R. Lund;  Ximing Cai
收藏  |  浏览/下载:8/0  |  提交时间:2021/12/15
Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载:14/0  |  提交时间:2021/07/27
A space hurricane over the Earth鈥檚 polar ionosphere 期刊论文
Nature Communications, 2021
作者:  Qing-He Zhang;  Yong-Liang Zhang;  Chi Wang;  Kjellmar Oksavik;  Larry R. Lyons;  Michael Lockwood;  Hui-Gen Yang;  Bin-Bin Tang;  ;  ran Idar Moen;  Zan-Yang Xing;  Yu-Zhang Ma;  Xiang-Yu Wang;  Ya-Fei Ning;  Li-Dong Xia
收藏  |  浏览/下载:15/0  |  提交时间:2021/03/02
A broadly protective antibody that targets the flavivirus NS1 protein 期刊论文
Science, 2021
作者:  Naphak Modhiran;  Hao Song;  Lidong Liu;  Cheryl Bletchly;  Lou Brillault;  Alberto A. Amarilla;  Xiaoying Xu;  Jianxun Qi;  Yan Chai;  Stacey T. M. Cheung;  Renee Traves;  Yin Xiang Setoh;  Summa Bibby;  Connor A. P. Scott;  Morgan E. Freney;  Natalee D. Newton;  Alexander A. Khromykh;  Keith J. Chappell;  David A. Muller;  Katryn J. Stacey;  Michael J. Landsberg;  Yi Shi;  George F. Gao;  Paul R. Young;  Daniel Watterson
收藏  |  浏览/下载:18/0  |  提交时间:2021/01/15
Plant-based and cell-based approaches to meat production 期刊论文
Nature Communications, 2020
作者:  Natalie R. Rubio;  Ning Xiang;  David L. Kaplan
收藏  |  浏览/下载:2/0  |  提交时间:2020/12/22
Origin of complexity in haemoglobin evolution 期刊论文
NATURE, 2020
作者:  Cheema, Suraj S.;  Kwon, Daewoong;  Shanker, Nirmaan;  dos Reis, Roberto;  Hsu, Shang-Lin;  Xiao, Jun;  Zhang, Haigang;  Wagner, Ryan;  Datar, Adhiraj;  McCarter, Margaret R.;  Serrao, Claudy R.;  Yadav, Ajay K.;  Karbasian, Golnaz;  Hsu, Cheng-Hsiang;  Tan, Ava J.;  Wang, Li-Chen;  Thakare, Vishal;  Zhang, Xiang;  Mehta, Apurva;  Karapetrova, Evguenia;  Chopdekar, Rajesh, V;  Shafer, Padraic;  Arenholz, Elke;  Hu, Chenming;  Proksch, Roger;  Ramesh, Ramamoorthy;  Ciston, Jim;  Salahuddin, Sayeef
收藏  |  浏览/下载:50/0  |  提交时间:2020/07/03

Most proteins associate into multimeric complexes with specific architectures(1,2), which often have functional properties such as cooperative ligand binding or allosteric regulation(3). No detailed knowledge is available about how any multimer and its functions arose during evolution. Here we use ancestral protein reconstruction and biophysical assays to elucidate the origins of vertebrate haemoglobin, a heterotetramer of paralogous alpha- and beta-subunits that mediates respiratory oxygen transport and exchange by cooperatively binding oxygen with moderate affinity. We show that modern haemoglobin evolved from an ancient monomer and characterize the historical '  missing link'  through which the modern tetramer evolved-a noncooperative homodimer with high oxygen affinity that existed before the gene duplication that generated distinct alpha- and beta-subunits. Reintroducing just two post-duplication historical substitutions into the ancestral protein is sufficient to cause strong tetramerization by creating favourable contacts with more ancient residues on the opposing subunit. These surface substitutions markedly reduce oxygen affinity and even confer cooperativity, because an ancient linkage between the oxygen binding site and the multimerization interface was already an intrinsic feature of the protein'  s structure. Our findings establish that evolution can produce new complex molecular structures and functions via simple genetic mechanisms that recruit existing biophysical features into higher-level architectures.


Experimental analysis of reconstructed ancestral globins reveals that haemoglobin'  s complex tetrameric structure and oxygen-binding functions evolved by simple genetic and biophysical mechanisms.


  
Intraplate volcanism originating from upwelling hydrous mantle transition zone 期刊论文
NATURE, 2020
作者:  Calabrese, Claudia;  Davidson, Natalie R.;  Demircioglu, Deniz;  Fonseca, Nuno A.;  He, Yao;  Kahles, Andre;  Kjong-Van Lehmann;  Liu, Fenglin;  Shiraishi, Yuichi;  Soulette, Cameron M.;  Urban, Lara;  Greger, Liliana;  Li, Siliang;  Liu, Dongbing;  Perry, Marc D.;  Xiang, Qian;  Zhang, Fan;  Zhang, Junjun;  Bailey, Peter;  Erkek, Serap;  Hoadley, Katherine A.;  Hou, Yong;  Huska, Matthew R.;  Kilpinen, Helena;  Korbel, Jan O.;  Marin, Maximillian G.;  Markowski, Julia;  Nandi, Tannistha;  Pan-Hammarstrom, Qiang;  Pedamallu, Chandra Sekhar;  Siebert, Reiner;  Stark, Stefan G.;  Su, Hong;  Tan, Patrick;  Waszak, Sebastian M.;  Yung, Christina;  Zhu, Shida;  Awadalla, Philip;  Creighton, Chad J.;  Meyerson, Matthew;  Ouellette, B. F. Francis;  Wu, Kui;  Yang, Huanming;  Brazma, Alvis;  Brooks, Angela N.;  Goke, Jonathan;  Raetsch, Gunnar;  Schwarz, Roland F.;  Stegle, Oliver;  Zhang, Zemin
收藏  |  浏览/下载:71/0  |  提交时间:2020/05/13

Most magmatism occurring on Earth is conventionally attributed to passive mantle upwelling at mid-ocean ridges, to slab devolatilization at subduction zones, or to mantle plumes. However, the widespread Cenozoic intraplate volcanism in northeast China(1-3) and the young petit-spot volcanoes(4-7) offshore of the Japan Trench cannot readily be associated with any of these mechanisms. In addition, the mantle beneath these types of volcanism is characterized by zones of anomalously low seismic velocity above and below the transition zone(8-12) (a mantle level located at depths between 410 and 660 kilometres). A comprehensive interpretation of these phenomena is lacking. Here we show that most (or possibly all) of the intraplate and petit-spot volcanism and low-velocity zones around the Japanese subduction zone can be explained by the Cenozoic interaction of the subducting Pacific slab with a hydrous mantle transition zone. Numerical modelling indicates that 0.2 to 0.3 weight per cent of water dissolved in mantle minerals that are driven out from the transition zone in response to subduction and retreat of a tectonic plate is sufficient to reproduce the observations. This suggests that a critical amount of water may have accumulated in the transition zone around this subduction zone, as well as in others of the Tethyan tectonic belt(13) that are characterized by intraplate or petit-spot volcanism and low-velocity zones in the underlying mantle.


The widespread intraplate volcanism in northeast China and the unusual '  petit-spot'  volcanoes offshore Japan could have resulted from the interaction of the subducting Pacific slab with a hydrous mantle transition zone.


  
Symbiont population control by host-symbiont metabolic interaction in Symbiodiniaceae-cnidarian associations 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Xiang, Tingting;  Lehnert, Erik;  Jinkerson, Robert E.;  Clowez, Sophie;  Kim, Rick G.;  DeNofrio, Jan C.;  Pringle, John R.;  Grossman, Arthur R.
收藏  |  浏览/下载:2/0  |  提交时间:2020/05/13
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Li, Zenggang;  Ivanov, Andrei A.;  Su, Rina;  Gonzalez-Pecchi, Valentina;  Qi, Qi;  Liu, Songlin;  Webber, Philip;  McMillan, Elizabeth;  Rusnak, Lauren;  Pham, Cau;  Chen, Xiaoqian;  Mo, Xiulei;  Revennaugh, Brian;  Zhou, Wei;  Marcus, Adam;  Harati, Sahar;  Chen, Xiang;  Johns, Margaret A.;  White, Michael A.;  Moreno, Carlos;  Cooper, Lee A. D.;  Du, Yuhong;  Khuri, Fadlo R.;  Fu, Haian
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours 期刊论文
NATURE, 2018, 555 (7696) : 371-+
作者:  Ma, Xiaotu;  Liu, Yu;  Liu, Yanling;  Alexandrov, Ludmil B.;  Edmonson, Michael N.;  Gawad, Charles;  Zhou, Xin;  Li, Yongjin;  Rusch, Michael C.;  Easton, John;  Huether, Robert;  Gonzalez-Pena, Veronica;  Wilkinson, Mark R.;  Hermida, Leandro C.;  Davis, Sean;  Sioson, Edgar;  Pounds, Stanley;  Cao, Xueyuan;  Ries, Rhonda E.;  Wang, Zhaoming;  Chen, Xiang;  Dong, Li;  Diskin, Sharon J.;  Smith, Malcolm A.;  Auvil, Jaime M. Guidry;  Meltzer, Paul S.;  Lau, Ching C.;  Perlman, Elizabeth J.;  Maris, John M.;  Meshinchi, Soheil;  Hunger, Stephen P.;  Gerhard, Daniela S.;  Zhang, Jinghui
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27