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Tectonic transition from oceanic subduction to continental collision: New geochemical evidence from Early-Middle Triassic mafic igneous rocks in southern Liaodong Peninsula, east-central China 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1469-1488
作者:  Fang, Wei;  Dai, Li-Qun;  Zheng, Yong-Fei;  Zhao, Zi-Fu;  Ma, Li-Tao
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
Geochemical evidence for the production of granitoids through reworking of the juvenile mafic arc crust in the Gangdese orogen, southern Tibet 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1347-1364
作者:  Tang, Yu-Wei;  Chen, Long;  Zhao, Zi-Fu;  Zheng, Yong-Fei
收藏  |  浏览/下载:6/0  |  提交时间:2020/08/18
Evaluation of multiple gridded precipitation datasets for the arid region of northwestern China 期刊论文
ATMOSPHERIC RESEARCH, 2020, 236
作者:  Yao, Junqiang;  Chen, Yaning;  Yu, Xiaojing;  Zhao, Yong;  Guan, Xuefeng;  Yang, Lianmei
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
Gridded precipitation  Multiple datasets  Systematically evaluate  Arid region of northwestern China (ARNC)  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Mutational signature in colorectal cancer caused by genotoxic pks(+)E. coli 期刊论文
NATURE, 2020, 580 (7802) : 269-+
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin(3). This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks in cultured cells(3). Here we expose human intestinal organoids to genotoxic pks(+)E. coli by repeated luminal injection over five months. Whole-genome sequencing of clonal organoids before and after this exposure revealed a distinct mutational signature that was absent from organoids injected with isogenic pks-mutant bacteria. The same mutational signature was detected in a subset of 5,876 human cancer genomes from two independent cohorts, predominantly in colorectal cancer. Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.


Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks(+) island develop a distinct mutational signature associated with colorectal cancer.


  
Pollution exacerbates China's water scarcity and its regional inequality 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Ma, Ting;  Sun, Siao;  Fu, Guangtao;  Hall, Jim W.;  Ni, Yong;  He, Lihuan;  Yi, Jiawei;  Zhao, Na;  Du, Yunyan;  Pei, Tao;  Cheng, Weiming;  Song, Ci;  Fang, Chuanglin;  Zhou, Chenghu
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
Understanding Terrestrial Water Storage Declining Trends in the Yellow River Basin 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (23) : 12963-12984
作者:  Jing, Wenlong;  Yao, Ling;  Zhao, Xiaodan;  Zhang, Pengyan;  Liu, Yangxiaoyue;  Xia, Xiaolin;  Song, Jia;  Yang, Ji;  Li, Yong;  Zhou, Chenghu
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/17
Understanding Terrestrial Water Storage Declining Trends in the Yellow River Basin 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Jing, Wenlong;  Yao, Ling;  Zhao, Xiaodan;  Zhang, Pengyan;  Liu, Yangxiaoyue;  Xia, Xiaolin;  Song, Jia;  Yang, Ji;  Li, Yong;  Zhou, Chenghu
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
The Yellow River Basin  terrestrial water storage  GRACE satellites  land surface model  hydrology model  
The Amplified Arctic Warming in the Recent Decades may Have Been Overestimated by CMIP5 Models 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (22) : 13338-13345
作者:  Huang, Jianbin;  Ou, Tinghai;  Chen, Deliang;  Luo, Yong;  Zhao, Zongci
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/17