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Measurement report: Distinct size dependence and diurnal variation in organic aerosol hygroscopicity, volatility, and cloud condensation nuclei activity at a rural site in the Pearl River Delta (PRD) region, China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Mingfu Cai, Shan Huang, Baoling Liang, Qibin Sun, Li Liu, Bin Yuan, Min Shao, Weiwei Hu, Wei Chen, Qicong Song, Wei Li, Yuwen Peng, Zelong Wang, Duohong Chen, Haobo Tan, Hanbin Xu, Fei Li, Xuejiao Deng, Tao Deng, Jiaren Sun, and Jun Zhao
收藏  |  浏览/下载:15/0  |  提交时间:2022/06/24
High concentration of ultrafine particles in the Amazon free troposphere produced by organic new particle formation 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Bin Zhao;  Manish Shrivastava;  Neil M. Donahue;  Hamish Gordon;  Meredith Schervish;  John E. Shilling;  Rahul A. Zaveri;  Jian Wang;  Meinrat O. Andreae;  Chun Zhao;  Brian Gaudet;  Ying Liu;  Jiwen Fan;  Jerome D. Fast
收藏  |  浏览/下载:12/0  |  提交时间:2020/10/12
Atmospheric heating rate due to black carbon aerosols: Uncertainties and impact factors 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Lu, Qiao;  Liu, Chao;  Zhao, Delong;  Zeng, Chen;  Li, Jing;  Lu, Chunsong;  Wang, Jiandong;  Zhu, Bin
收藏  |  浏览/下载:32/0  |  提交时间:2020/08/18
Black carbon  Radiative forcing  Heating rate  Vertical distribution  
Air Quality Impact of the Northern California Camp Fire of November 2018 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Brigitte Rooney, Yuan Wang, Jonathan H. Jiang, Bin Zhao, Zhao-Cheng Zeng, and John H. Seinfeld
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/09
Effect of NOX, O3 and NH3 on sulfur isotope composition duringheterogeneous oxidation of SO2: a laboratory investigation 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Zhaobing Guo, Mingyi Xu, Yuxuan He, Shuo Gao, Chenmin Xu, Bin Zhu, Qingjun Guo, Xiaoyu Shen, Shuang Zhao, and Pengxiang Qiu
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/09
Remote moisture sources for 6-hour summer precipitation over the Southeastern Tibetan Plateau and its effects on precipitation intensity 期刊论文
ATMOSPHERIC RESEARCH, 2020, 236
作者:  Yang, Shuai;  Zhang, Wei;  Chen, Bin;  Xu, XiangDe;  Zhao, Ruiyu
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
LA-MC-ICP-MS U-Pb dating of low-U garnets reveals multiple episodes of skarn formation in the volcanic-hosted iron mineralization system, Awulale belt, Central Asia 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1031-1045
作者:  Yan, Shuang;  Zhou, Renjie;  Niu, He-Cai;  Feng, Yue-xing;  Ai Duc Nguyen;  Zhao, Zhen-hua;  Yang, Wu-Bin;  Dong, Qian;  Zhao, Jian-xin
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/02
LA-MC-ICP-MS U-Pb dating of low-U garnets reveals multiple episodes of skarn formation in the volcanic-hosted iron mineralization system, Awulale belt, Central Asia (vol 132, pg 1031, 2020) 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1046-1046
作者:  Yan, Shuang;  Zhou, Renjie;  Niu, He-Cai;  Feng, Yue-xing;  Ai Duc Nguyen;  Zhao, Zhen-hua;  Yang, Wu-Bin;  Dong, Qian;  Zhao, Jian-xin
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/02
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).