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Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Contrasting size-resolved hygroscopicity of fine particles derived by HTDMA and HR-ToF-AMS measurements between summer and winter in Beijing: the impacts of aerosol aging and local emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 915-929
作者:  Fan, Xinxin;  Liu, Jieyao;  Zhang, Fang;  Chen, Lu;  Collins, Don;  Xu, Weiqi;  Jin, Xiaoai;  Ren, Jingye;  Wang, Yuying;  Wu, Hao;  Li, Shangze;  Sun, Yele;  Li, Zhanqing
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/02
Significant contribution of organics to aerosol liquid water content in winter in Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 901-914
作者:  Jin, Xiaoai;  Wang, Yuying;  Li, Zhanqing;  Zhang, Fang;  Xu, Weiqi;  Sun, Yele;  Fan, Xinxin;  Chen, Guangyu;  Wu, Hao;  Ren, Jingye;  Wang, Qiuyan;  Cribb, Maureen
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Significantly Enhanced Aerosol CCN Activity and Number Concentrations by Nucleation-Initiated Haze Events: A Case Study in Urban Beijing 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (24) : 14102-14113
作者:  Zhang, Fang;  Ren, Jingye;  Fan, Tianyi;  Chen, Lu;  Xu, Weiqi;  Sun, Yele;  Zhang, Renyi;  Liu, Jieyao;  Jiang, Sihui;  Jin, Xiaoai;  Wu, Hao;  Li, Shangze;  Cribb, Maureen C.;  Li, Zhanqing
收藏  |  浏览/下载：11/0  |  提交时间：2020/02/17
Structure of the RSC complex bound to the nucleosome 期刊论文
SCIENCE, 2019, 366 (6467) : 838-+
作者:  Ye, Youpi;  Wu, Hao;  Chen, Kangjing;  Clapier, Cedric R.;  Verma, Naveen;  Zhang, Wenhao;  Deng, Haiteng;  Cairns, Bradley R.;  Gao, Ning;  Chen, Zhucheng
收藏  |  浏览/下载：11/0  |  提交时间：2020/02/17
Distinct Ultrafine- and Accumulation-Mode Particle Properties in Clean and Polluted Urban Environments 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Wang, Yuying;  Li, Zhanqing;  Zhang, Renyi;  Jin, Xiaoai;  Xu, Weiqi;  Fan, Xinxin;  Wu, Hao;  Zhang, Fang;  Sun, Yele;  Wang, Qiuyan;  Cribb, Maureen;  Hu, Dawei
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
aerosol properties  aerosol hygroscopicity  H-TDMA  aerosol formation process  
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWPI inhibitory pathway 期刊论文
SCIENCE, 2019, 364 (6441) : 651-+
作者:  Lee, Yu-Ru;  Chen, Ming;  Lee, Jonathan D.;  Zhang, Jinfang;  Lin, Shu-Yu;  Fu, Tian-Min;  Chen, Hao;  Ishikawa, Tomold;  Chiang, Shang-Yin;  Katon, Jesse;  Zhang, Yang;  Shulga, Yulia V.;  Bester, Assaf C.;  Fung, Jacqueline;  Monteleone, Emanuele;  Wan, Lixin;  Shen, Chen;  Hsu, Chil-Hung;  Papa, Antonella;  Clohessy, John G.;  Teruya-Feldstein, Julie;  Jain, Suresh;  Wu, Hao;  Matesic, Lydia;  Chen, Ruey-Hwa;  Wei, Wenyi;  Pandolfi, Pier Paolo
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27