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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Qian Zhang;  Paul Bastard;  Zhiyong Liu;  Jérémie Le Pen;  Marcela Moncada-Velez;  Jie Chen;  Masato Ogishi;  Ira K. D. Sabli;  Stephanie Hodeib;  Cecilia Korol;  Jérémie Rosain;  Kaya Bilguvar;  Junqiang Ye;  Alexandre Bolze;  Benedetta Bigio;  Rui Yang;  Andrés Augusto Arias;  Qinhua Zhou;  Yu Zhang;  Fanny Onodi;  Sarantis Korniotis;  Léa Karpf;  Quentin Philippot;  Marwa Chbihi;  Lucie Bonnet-Madin;  Karim Dorgham;  Nikaïa Smith;  William M. Schneider;  Brandon S. Razooky;  Hans-Heinrich Hoffmann;  Eleftherios Michailidis;  Leen Moens;  Ji Eun Han;  Lazaro Lorenzo;  Lucy Bizien;  Philip Meade;  Anna-Lena Neehus;  Aileen Camille Ugurbil;  Aurélien Corneau;  Gaspard Kerner;  Peng Zhang;  Franck Rapaport;  Yoann Seeleuthner;  Jeremy Manry;  Cecile Masson;  Yohann Schmitt;  Agatha Schlüter;  Tom Le Voyer;  Taushif Khan;  Juan Li;  Jacques Fellay;  Lucie Roussel;  Mohammad Shahrooei;  Mohammed F. Alosaimi;  Davood Mansouri;  Haya Al-Saud;  Fahd Al-Mulla;  Feras Almourfi;  Saleh Zaid Al-Muhsen;  Fahad Alsohime;  Saeed Al Turki;  Rana Hasanato;  Diederik van de Beek;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D’Angio’;  Paolo Bonfanti;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Andrew J. Oler;  Miranda F. Tompkins;  Camille Alba;  Isabelle Vandernoot;  Jean-Christophe Goffard;  Guillaume Smits;  Isabelle Migeotte;  Filomeen Haerynck;  Pere Soler-Palacin;  Andrea Martin-Nalda;  Roger Colobran;  Pierre-Emmanuel Morange;  Sevgi Keles;  Fatma Çölkesen;  Tayfun Ozcelik;  Kadriye Kart Yasar;  Sevtap Senoglu;  Şemsi Nur Karabela;  Carlos Rodríguez-Gallego;  Giuseppe Novelli;  Sami Hraiech;  Yacine Tandjaoui-Lambiotte;  Xavier Duval;  Cédric Laouénan;  COVID-STORM Clinicians†;  COVID Clinicians†;  Imagine COVID Group†;  French COVID Cohort Study Group†;  CoV-Contact Cohort†;  Amsterdam UMC Covid-19 Biobank†;  COVID Human Genetic Effort†;  NIAID-USUHS/TAGC COVID Immunity Group†;  Andrew L. Snow;  Clifton L. Dalgard;  Joshua D. Milner;  Donald C. Vinh;  Trine H. Mogensen;  Nico Marr;  András N. Spaan;  Bertrand Boisson;  Stéphanie Boisson-Dupuis;  Jacinta Bustamante;  Anne Puel;  Michael J. Ciancanelli;  Isabelle Meyts;  Tom Maniatis;  Vassili Soumelis;  Ali Amara;  Michel Nussenzweig;  Adolfo García-Sastre;  Florian Krammer;  Aurora Pujol;  Darragh Duffy;  Richard P. Lifton;  Shen-Ying Zhang;  Guy Gorochov;  Vivien Béziat;  Emmanuelle Jouanguy;  Vanessa Sancho-Shimizu;  Charles M. Rice;  Laurent Abel;  Luigi D. Notarangelo;  Aurélie Cobat;  Helen C. Su;  Jean-Laurent Casanova
收藏  |  浏览/下载:21/0  |  提交时间:2020/10/26
Can N2O emissions offset the benefits from soil organic carbon storage? 期刊论文
Global Change Biology, 2020
作者:  Bertrand Guenet;  Benoit Gabrielle;  Claire Chenu;  Dominique Arrouays;  ;  ;  me Balesdent;  Martial Bernoux;  Elisa Bruni;  Jean‐;  Pierre Caliman;  ;  mi Cardinael;  Songchao Chen;  Philippe Ciais;  Dominique Desbois;  Julien Fouche;  Stefan Frank;  Catherine Henault;  Emanuele Lugato;  Victoria Naipal;  Thomas Nesme;  Michael Obersteiner;  Sylvain Pellerin;  David S. Powlson;  Daniel P. Rasse;  Fré;  ;  ric Rees;  Jean‐;  Franç;  ois Soussana;  Yang Su;  Hanqin Tian;  Hugo Valin;  Feng Zhou
收藏  |  浏览/下载:16/0  |  提交时间:2020/10/12
A comprehensive quantification of global nitrous oxide sources and sinks 期刊论文
Nature, 2020
作者:  Hanqin Tian;  Rongting Xu;  Josep G. Canadell;  Rona L. Thompson;  Wilfried Winiwarter;  Parvadha Suntharalingam;  Eric A. Davidson;  Philippe Ciais;  Robert B. Jackson;  Greet Janssens-Maenhout;  Michael J. Prather;  Pierre Regnier;  Naiqing Pan;  Shufen Pan;  Glen P. Peters;  Hao Shi;  Francesco N. Tubiello;  ;  nke Zaehle;  Feng Zhou;  Almut Arneth;  Gianna Battaglia;  Sarah Berthet;  Laurent Bopp;  Alexander F. Bouwman;  Erik T. Buitenhuis;  Jinfeng Chang;  Martyn P. Chipperfield;  Shree R. S. Dangal;  Edward Dlugokencky;  James W. Elkins;  Bradley D. Eyre;  Bojie Fu;  Bradley Hall;  Akihiko Ito;  Fortunat Joos;  Paul B. Krummel;  Angela Landolfi;  Goulven G. Laruelle;  Ronny Lauerwald;  Wei Li;  Sebastian Lienert;  Taylor Maavara;  Michael MacLeod;  Dylan B. Millet;  Stefan Olin;  Prabir K. Patra;  Ronald G. Prinn;  Peter A. Raymond;  Daniel J. Ruiz;  Guido R. van der Werf;  Nicolas Vuichard;  Junjie Wang;  Ray F. Weiss;  Kelley C. Wells;  Chris Wilson;  Jia Yang;  Yuanzhi Yao
收藏  |  浏览/下载:23/0  |  提交时间:2020/10/12
A quantitative framework reveals ecological drivers of grassland microbial community assembly in response to warming 期刊论文
Nature Communications, 2020
作者:  Daliang Ning;  Mengting Yuan;  Linwei Wu;  Ya Zhang;  Xue Guo;  Xishu Zhou;  Yunfeng Yang;  Adam P. Arkin;  Mary K. Firestone;  Jizhong Zhou
收藏  |  浏览/下载:11/0  |  提交时间:2020/09/22
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants 期刊论文
Science, 2020
作者:  Siwei Zhang;  Hanwen Zhang;  Yifan Zhou;  Min Qiao;  Siming Zhao;  Alena Kozlova;  Jianxin Shi;  Alan R. Sanders;  Gao Wang;  Kaixuan Luo;  Subhajit Sengupta;  Siobhan West;  Sheng Qian;  Michael Streit;  Dimitrios Avramopoulos;  Chad A. Cowan;  Mengjie Chen;  Zhiping P. Pang;  Pablo V. Gejman;  Xin He;  Jubao Duan
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/09
CAN THE WORLD MAKE ENOUGH CORONAVIRUS VACCINE? 期刊论文
NATURE, 2020, 580 (7805) : 578-580
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Liu, Mingjie;  Jiang, Lei
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


  
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
The trend of the oxidants in boreal forest over 2007-2018: comprehensive modelling study with long-term measurements at SMEAR II, Finland 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Dean Chen, Putian Zhou, Tuomo Nieminen, Pontus Roldin, Ximeng Qi, Petri Clusius, Carlton Xavier, Lukas Pichelstorfer, Markku Kulmala, Pekka Rantala, Juho Aalto, Nina Sarnela, Pasi Kolari, Petri Keronen, Matti P. Rissanen, Metin Baykara, and Michael Boy
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
Very regular high-frequency pulsation modes in young intermediate-mass stars 期刊论文
NATURE, 2020, 581 (7807) : 147-+
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Jiang, Lei;  Liu, Mingjie
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Asteroseismology probes the internal structures of stars by using their natural pulsation frequencies(1). It relies on identifying sequences of pulsation modes that can be compared with theoretical models, which has been done successfully for many classes of pulsators, including low-mass solar-type stars(2), red giants(3), high-mass stars(4) and white dwarfs(5). However, a large group of pulsating stars of intermediate mass-the so-called delta Scuti stars-have rich pulsation spectra for which systematic mode identification has not hitherto been possible(6,7). This arises because only a seemingly random subset of possible modes are excited and because rapid rotation tends to spoil regular patterns(8-10). Here we report the detection of remarkably regular sequences of high-frequency pulsation modes in 60 intermediate-mass main-sequence stars, which enables definitive mode identification. The space motions of some of these stars indicate that they are members of known associations of young stars, as confirmed by modelling of their pulsation spectra.


The pulsation spectra of intermediate-mass stars (so-called delta Scuti stars) have been challenging to analyse, but new observations of 60 such stars reveal remarkably regular sequences of high-frequency pulsation modes.


  
Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Tao, Chunhui;  Seyfried, W. E., Jr.;  Lowell, R. P.;  Liu, Yunlong;  Liang, Jin;  Guo, Zhikui;  Ding, Kang;  Zhang, Huatian;  Liu, Jia;  Qiu, Lei;  Egorov, Igor;  Liao, Shili;  Zhao, Minghui;  Zhou, Jianping;  Deng, Xianming;  Li, Huaiming;  Wang, Hanchuang;  Cai, Wei;  Zhang, Guoyin;  Zhou, Hongwei;  Lin, Jian;  Li, Wei
收藏  |  浏览/下载:19/0  |  提交时间:2020/05/13