GSTDTAP

浏览/检索结果: 共56条,第1-10条 帮助

限定条件                
已选(0)清除 条数/页:   排序方式:
Aerosols consistently suppress the convective boundary layer development 期刊论文
Atmospheric Research, 2022
作者:  Xiaoyan Zhang, Changjie Cai, Xiao-Ming Hu, Lan Gao, ... Haishan Chen
收藏  |  浏览/下载:9/0  |  提交时间:2022/02/16
On the distribution of helicity in the tropical cyclone boundary layer from dropsonde composites 期刊论文
Atmospheric Research, 2020
作者:  Nuo Chen, Jie Tang, Jun A. Zhang, Lei-Ming Ma, Hui Yu
收藏  |  浏览/下载:5/0  |  提交时间:2020/10/12
CHLOROQUINE HYPE DERAILS CORONAVIRUS DRUG TRIALS 期刊论文
NATURE, 2020, 580 (7805) : 573-573
作者:  Hu, Minjie;  Zheng, Xiaobin;  Fan, Chen-Ming;  Zheng, Yixian
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

With politicians touting the potential benefits of malaria drugs to fight COVID-19, some people are turning away from clinical trials of other therapies.


With politicians touting the potential benefits of malaria drugs to fight COVID-19, some people are turning away from clinical trials of other therapies.


  
Chesapeake Bay acidification buffered by spatially decoupled carbonate mineral cycling 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 441-+
作者:  Su, Jianzhong;  Cai, Wei-Jun;  Brodeur, Jean;  Chen, Baoshan;  Hussain, Najid;  Yao, Yichen;  Ni, Chaoying;  Testa, Jeremy M.;  Li, Ming;  Xie, Xiaohui;  Ni, Wenfei;  Scaboo, K. Michael;  Xu, Yuan-yuan;  Cornwell, Jeffrey;  Gurbisz, Cassie;  Owens, Michael S.;  Waldbusser, George G.;  Dai, Minhan;  Kemp, W. Michael
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/09
Strain engineering and epitaxial stabilization of halide perovskites 期刊论文
NATURE, 2020, 577 (7789) : 209-+
作者:  Chen, Yimu;  Lei, Yusheng;  Li, Yuheng;  Yu, Yugang;  Cai, Jinze;  Chiu, Ming-Hui;  Rao, Rahul;  Gu, Yue;  Wang, Chunfeng;  Choi, Woojin;  Hu, Hongjie;  Wang, Chonghe;  Li, Yang;  Song, Jiawei;  Zhang, Jingxin;  Qi, Baiyan;  Lin, Muyang;  Zhang, Zhuorui;  Islam, Ahmad E.;  Maruyama, Benji;  Dayeh, Shadi;  Li, Lain-Jong;  Yang, Kesong;  Lo, Yu-Hwa;  Xu, Sheng
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/03

Strain engineering is a powerful tool with which to enhance semiconductor device performance(1,2). Halide perovskites have shown great promise in device applications owing to their remarkable electronic and optoelectronic properties(3-5). Although applying strain to halide perovskites has been frequently attempted, including using hydrostatic pressurization(6-8), electrostriction(9), annealing(10-12), van der Waals force(13), thermal expansion mismatch(14), and heat-induced substrate phase transition(15), the controllable and device-compatible strain engineering of halide perovskites by chemical epitaxy remains a challenge, owing to the absence of suitable lattice-mismatched epitaxial substrates. Here we report the strained epitaxial growth of halide perovskite single-crystal thin films on lattice-mismatched halide perovskite substrates. We investigated strain engineering of a-formamidinium lead iodide (alpha-FAPbI(3)) using both experimental techniques and theoretical calculations. By tailoring the substrate composition-and therefore its lattice parameter-a compressive strain as high as 2.4 per cent is applied to the epitaxial alpha-FAPbI(3) thin film. We demonstrate that this strain effectively changes the crystal structure, reduces the bandgap and increases the hole mobility of alpha-FAPbI(3). Strained epitaxy is also shown to have a substantial stabilization effect on the alpha-FAPbI(3) phase owing to the synergistic effects of epitaxial stabilization and strain neutralization. As an example, strain engineering is applied to enhance the performance of an alpha-FAPbI(3)-based photodetector.


  
Impact of topography on black carbon transport to the southern Tibetan Plateau during the pre-monsoon season and its climatic implication 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 5923-5943
作者:  Zhang, Meixin;  Zhao, Chun;  Cong, Zhiyuan;  Du, Qiuyan;  Xu, Mingyue;  Chen, Yu;  Chen, Ming;  Li, Rui;  Fu, Yunfei;  Zhong, Lei;  Kang, Shichang;  Zhao, Delong;  Yang, Yan
收藏  |  浏览/下载:17/0  |  提交时间:2020/05/20
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
A preliminary study on wind tunnel simulations of the explosive growth and dissipation of fine particulate matter in ambient air 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Xu, Jingxin;  Zhu, Fahua;  Wang, Sheng;  Zhao, Xiuyong;  Zhang, Ming;  Ge, Xinlei;  Wang, Junfeng;  Tian, Wenxin;  Wang, Liwen;  Yang, Liu;  Ding, Li;  Lu, Xiaobo;  Chen, Xinxin;  Zheng, Youfei;  Guo, Zhaobing
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Wind tunnel  Fine particulate matter  Explosive growth  Dissipation  Relative humidity  Liquid water content  
Generation of the 105-100 Ma Dagze volcanic rocks in the north Lhasa Terrane by lower crustal melting at different temperature and depth: Implications for tectonic transition 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (5-6) : 1257-1272
作者:  Zeng, Yun-Chuan;  Xu, Ji-Feng;  Huang, Feng;  Li, Ming-Jian;  Chen, Qin
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.