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In many neurodegenerative disorders, the spread of protein aggregates underlies disease progression in the brain. A receptor molecule has now been found that mediates the neuronal uptake of one such harmful protein. See p.381

Two threads of research in the quest for methods that predict the 3D structures of proteins from their amino-acid sequences have become fully intertwined. The result is a leap forward in the accuracy of predictions.

The structure of thyroglobulin, the enormous protein that acts as a precursor for thyroid hormones, has been determined, and its hormone-forming tyrosine amino-acid residues have been identified.

Fresh insight into the biosynthesis of thyroid hormones.

A zinc-sensing ion channel, Hodor, has now been found in the intestine of fruit flies. Hodor activates the TORC1 signalling pathway, and in doing so, influences organism-wide growth and metabolism.