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Atmospheric heating rate due to black carbon aerosols: Uncertainties and impact factors 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Lu, Qiao;  Liu, Chao;  Zhao, Delong;  Zeng, Chen;  Li, Jing;  Lu, Chunsong;  Wang, Jiandong;  Zhu, Bin
收藏  |  浏览/下载:35/0  |  提交时间:2020/08/18
Black carbon  Radiative forcing  Heating rate  Vertical distribution  
Localization and Invigoration of Mei-yu Front Rainfall due to Aerosol-Cloud Interactions: A Preliminary Assessment Based on WRF Simulations and IMFRE 2018 Field Observations 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Liu, Lin;  Cui, Chunguang;  Deng, Yi;  Zhou, Zhimin;  Hu, Yang;  Wang, Bin;  Ren, Jing;  Cai, Zhaoxin;  Bai, Yongqing;  Yang, Junmei;  Dong, Xiquan
收藏  |  浏览/下载:22/0  |  提交时间:2020/08/18
aerosol-cloud interactions  Mei-yu front  microphysical properties  thermodynamic and dynamic effects  
Petrogenesis of the Cretaceous granitoids in Zhejiang, northeast South China Block and their implications for episodic retreat and roll-back of the Paleo-Pacific Plate 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1514-1536
作者:  Tao, Lu;  Pan, Fa-Bin;  Liu, Rong;  Jin, Chong;  Jia, Bao-Jian;  He, Xiaobo
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
Strong anthropogenic control of secondary organic aerosol formation from isoprene in Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7531-7552
作者:  Bryant, Daniel J.;  Dixon, William J.;  Hopkins, James R.;  Dunmore, Rachel E.;  Pereira, Kelly;  Shaw, Marvin;  Squires, Freya A.;  Bannan, Thomas J.;  Mehra, Archit;  Worrall, Stephen D.;  Bacak, Asan;  Coe, Hugh;  Percival, Carl J.;  Whalley, Lisa K.;  Heard, Dwayne E.;  Slater, Eloise J.;  Ouyang, Bin;  Cui, Tianqu;  Surratt, Jason D.;  Liu, Di;  Shi, Zongbo;  Harrison, Roy;  Sun, Yele;  Xu, Weiqi;  Lewis, Alastair C.;  Lee, James D.;  Rickard, Andrew R.;  Hamilton, Jacqueline F.
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/18
El Nino Diversity Across Boreal Spring Predictability Barrier 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Wang, Bin;  Luo, Xiao;  Sun, Weiyi;  Yang, Young-Min;  Liu, Jian
收藏  |  浏览/下载:17/0  |  提交时间:2020/06/16
El Nino diversity  El Nino transition  k-means cluster analysis  El Nino precursors  El Nino impact  spring predictability barrier  
"Warm Arctic-Cold Siberia" as an Internal Mode Instigated by North Atlantic Warming 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Jin, Chunhan;  Wang, Bin;  Yang, Young-Min;  Liu, Jian
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
"Warm Arctic-Cold Siberia" pattern  AMO  multi-decadal variations  internal mode of variability  Asian winter monsoon  greenhouse gases forcing  
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Corncob cellulose nanosphere as an eco-friendly detergent 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (6) : 448-458
作者:  Liu, Bin;  Li, Tao;  Wang, Wenya;  Sagis, Leonard M. C.;  Yuan, Qipeng;  Lei, Xingen;  Stuart, Martien A. Cohen;  Li, Dan;  Bao, Cheng;  Bai, Jie;  Yu, Zhengquan;  Ren, Fazheng;  Li, Yuan
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13