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A machine learning examination of hydroxyl radical differences among model simulations for CCMI-1 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (3) : 1341-1361
作者:  Nicely, Julie M.;  Duncan, Bryan N.;  Hanisco, Thomas F.;  Wolfe, Glenn M.;  Salawitch, Ross J.;  Deushi, Makoto;  Haslerud, Amund S.;  Joeckel, Patrick;  Josse, Beatrice;  Kinnison, Douglas E.;  Klekociuk, Andrew;  Manyin, Michael E.;  Marecal, Virginie;  Morgenstern, Olaf;  Murray, Lee T.;  Myhre, Gunnar;  Oman, Luke D.;  Pitari, Giovanni;  Pozzer, Andrea;  Quaglia, Ilaria;  Revell, Laura E.;  Rozanov, Eugene;  Stenke, Andrea;  Stone, Kane;  Strahan, Susan;  Tames, Simone;  Tost, Holger;  Westervelt, Daniel M.;  Zeng, Guang
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/02
Genomic basis for RNA alterations in cancer 期刊论文
NATURE, 2020, 578 (7793) : 129-+
作者:  Petitprez, Florent;  39;han
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/03

Transcript alterations often result from somatic changes in cancer genomes(1). Various forms of RNA alterations have been described in cancer, including overexpression(2), altered splicing(3) and gene fusions(4)  however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(5). Using matched whole-genome sequencing data, we associated several categories of RNA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms. Somatic copy-number alterations were the major drivers of variations in total gene and allele-specific expression. We identified 649 associations of somatic single-nucleotide variants with gene expression in cis, of which 68.4% involved associations with flanking non-coding regions of the gene. We found 1,900 splicing alterations associated with somatic mutations, including the formation of exons within introns in proximity to Alu elements. In addition, 82% of gene fusions were associated with structural variants, including 75 of a new class, termed '  bridged'  fusions, in which a third genomic location bridges two genes. We observed transcriptomic alteration signatures that differ between cancer types and have associations with variations in DNA mutational signatures. This compendium of RNA alterations in the genomic context provides a rich resource for identifying genes and mechanisms that are functionally implicated in cancer.


  
The mechanisms and meteorological drivers of the summertime ozone-temperature relationship 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (20) : 13367-13381
作者:  Porter, William C.;  Heald, Colette L.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Differential soil fungus accumulation and density dependence of trees in a subtropical forest 期刊论文
SCIENCE, 2019, 366 (6461) : 124-+
作者:  Chen, Lei;  Swenson, Nathan G.;  Ji, Niuniu;  Mi, Xiangcheng;  Ren, Haibao;  Guo, Liangdong;  Ma, Keping
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Impact of El Nino-Southern Oscillation on the interannual variability of methane and tropospheric ozone 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (13) : 8669-8686
作者:  Rowlinson, Matthew J.;  Rap, Alexandru;  Arnold, Stephen R.;  Pope, Richard J.;  Chipperfield, Martyn P.;  McNorton, Joe;  Forster, Piers;  Gordon, Hamish;  Pringle, Kirsty J.;  Feng, Wuhu;  Kerridge, Brian J.;  Latter, Barry L.;  Siddans, Richard
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Extratropical age of air trends and causative factors in climate projection simulations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (11) : 7627-7647
作者:  Sacha, Petr;  Eichinger, Roland;  Garny, Hella;  Pisoft, Petr;  Dietmueller, Simone;  de la Torre, Laura;  Plummer, David A.;  Joeckel, Patrick;  Morgenstern, Olaf;  Zeng, Guang;  Butchart, Neal;  Anel, Juan A.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/26
Herbivores as drivers of negative density dependence in tropical forest saplings 期刊论文
SCIENCE, 2019, 363 (6432) : 1213-+
作者:  Forrister, Dale L.;  Endara, Maria-Jose;  Younkin, Gordon C.;  Coley, Phyllis D.;  Kursar, Thomas A.
收藏  |  浏览/下载：2/0  |  提交时间：2019/11/27
Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage 期刊论文
SCIENCE, 2018, 362 (6410) : 91-95
作者:  Park, Jung Wook;  Lee, John K.;  Sheu, Katherine M.;  Wang, Liang;  Balanis, Nikolas G.;  Kim Nguyen;  Smith, Bryan A.;  Cheng, Chen;  Tsai, Brandon L.;  Cheng, Donghui;  Huang, Jiaoti;  Kurdistani, Siavash K.;  Graeber, Thomas G.;  Witte, Owen N.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Fisheries bycatch risk to marine megafauna is intensified in Lagrangian coherent structures 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (28) : 7362-7367
作者:  Scales, Kylie L.;  Hazen, Elliott L.;  Jacox, Michael G.;  Castruccio, Frederic;  Maxwell, Sara M.;  Lewison, Rebecca L.;  Bograd, Steven J.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
ocean model  marine vertebrate  gillnet  Finite-Time Lyapunov Exponent  fronts  
Drivers and mechanisms of ocean deoxygenation 期刊论文
NATURE GEOSCIENCE, 2018, 11 (7) : 467-473
作者:  Oschlies, Andreas;  Brandt, Peter;  Stramma, Lothar;  Schmidtko, Sunke
收藏  |  浏览/下载：9/0  |  提交时间：2019/04/09