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MEASLES IS ON THE RISE - AND COVID-19 COULD MAKE IT WORSE 期刊论文
NATURE, 2020, 580 (7804) : 446-447
作者:  Ruan, Zheng;  Orozco, Ian J.;  Du, Juan;  Lu, Wei
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

The world'  s most contagious virus has killed thousands in the Democratic Republic of the Congo, and 23 countries have suspended measles vaccination campaigns as they cope with SARS-CoV-2. Credit: Junior Kannah/AFP Via Getty


The world'  s most contagious virus has killed thousands in the Democratic Republic of the Congo, and 23 countries have suspended measles vaccination campaigns as they cope with SARS-CoV-2.


  
Childhood vaccines and antibiotic use in low- and middle-income countries 期刊论文
NATURE, 2020, 581 (7806) : 94-+
作者:  Louca, Stilianos;  Pennell, Matthew W.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Vaccines may reduce the burden of antimicrobial resistance, in part by preventing infections for which treatment often includes the use of antibiotics(1-4). However, the effects of vaccination on antibiotic consumption remain poorly understood-especially in low- and middle-income countries (LMICs), where the burden of antimicrobial resistance is greatest(5). Here we show that vaccines that have recently been implemented in the World Health Organization'  s Expanded Programme on Immunization reduce antibiotic consumption substantially among children under five years of age in LMICs. By analysing data from large-scale studies of households, we estimate that pneumococcal conjugate vaccines and live attenuated rotavirus vaccines confer 19.7% (95% confidence interval, 3.4-43.4%) and 11.4% (4.0-18.6%) protection against antibiotic-treated episodes of acute respiratory infection and diarrhoea, respectively, in age groups that experience the greatest disease burden attributable to the vaccine-targeted pathogens(6,7). Under current coverage levels, pneumococcal and rotavirus vaccines prevent 23.8 million and 13.6 million episodes of antibiotic-treated illness, respectively, among children under five years of age in LMICs each year. Direct protection resulting from the achievement of universal coverage targets for these vaccines could prevent an additional 40.0 million episodes of antibiotic-treated illness. This evidence supports the prioritization of vaccines within the global strategy to combat antimicrobial resistance(8).


Pneumococcal and rotavirus vaccines have reduced antibiotic consumption substantially among children under five years old in low- and middle-income countries  however, this effect could be doubled if all countries were to implement vaccination programmes and meet universal vaccine coverage targets.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
A global drive towards elimination 期刊论文
NATURE, 2020, 580 (7804) : S2-S4
作者:  Gallina, Irene;  Duxin, Julien P.
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/03

Vaccination is picking up where screening left off to reduce the incidence of one of the most common cancers in women.


Vaccination is picking up where screening left off to reduce the incidence of one of the most common cancers in women.


  
Optimizing the impact of low-efficacy influenza vaccines 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (20) : 5151-5156
作者:  Sah, Pratha;  Medlock, Jan;  Fitzpatrick, Meagan C.;  Singer, Burton H.;  Galvani, Alison P.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
mathematical model  age structured  vaccination  DALY  hospitalization  
The International AIDS Vaccine Initiative's capacity building activities in East Africa: Evaluating progress and impacts in Kenya, Uganda and Rwanda 科技报告
来源:Rand Corporation. 出版年: 2015
作者:  Gavin Cochrane;  Enora Robin;  Rebecca Hanlin;  Sophie Castle-Clarke;  Calum MacLure;  Sarah Parks;  Joanna Chataway
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/05
Science, Technology and Innovation Policy  HIV and AIDS  Health Care Program Evaluation  Capacity Building  Vaccination  Kenya  Rwanda  Uganda  
A Blueprint for Improving the Promotion and Delivery of Adult Vaccination in the United States 科技报告
来源:Rand Corporation. 出版年: 2012
作者:  Katherine M. Harris;  Lori Uscher-Pines;  Soeren Mattke;  Arthur L. Kellermann
收藏  |  浏览/下载:2/0  |  提交时间:2019/04/05
Influenza  Adult Populations  Vaccination  United States  Economists  Medical Professionals