GSTDTAP

浏览/检索结果: 共13条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
Population flow drives spatio-temporal distribution of COVID-19 in China 期刊论文
NATURE, 2020
作者:  Fernandez, Diego Carlos;  Komal, Ruchi;  Langel, Jennifer;  Ma, Jun;  Duy, Phan Q.;  Penzo, Mario A.;  Zhao, Haiqing;  Hattar, Samer
收藏  |  浏览/下载:70/0  |  提交时间:2020/07/03

Sudden, large-scale and diffuse human migration can amplify localized outbreaks of disease into widespread epidemics(1-4). Rapid and accurate tracking of aggregate population flows may therefore be epidemiologically informative. Here we use 11,478,484 counts of mobile phone data from individuals leaving or transiting through the prefecture of Wuhan between 1 January and 24 January 2020 as they moved to 296 prefectures throughout mainland China. First, we document the efficacy of quarantine in ceasing movement. Second, we show that the distribution of population outflow from Wuhan accurately predicts the relative frequency and geographical distribution of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) until 19 February 2020, across mainland China. Third, we develop a spatio-temporal '  risk source'  model that leverages population flow data (which operationalize the risk that emanates from epidemic epicentres) not only to forecast the distribution of confirmed cases, but also to identify regions that have a high risk of transmission at an early stage. Fourth, we use this risk source model to statistically derive the geographical spread of COVID-19 and the growth pattern based on the population outflow from Wuhan  the model yields a benchmark trend and an index for assessing the risk of community transmission of COVID-19 over time for different locations. This approach can be used by policy-makers in any nation with available data to make rapid and accurate risk assessments and to plan the allocation of limited resources ahead of ongoing outbreaks.


Modelling of population flows in China enables the forecasting of the distribution of confirmed cases of COVID-19 and the identification of areas at high risk of SARS-CoV-2 transmission at an early stage.


  
Targeting of temperate phages drives loss of type I CRISPR-Cas systems 期刊论文
NATURE, 2020, 578 (7793) : 149-+
作者:  Xiang, Lifeng;  Yin, Yu;  Zheng, Yun;  Ma, Yanping;  Li, Yonggang;  Zhao, Zhigang;  Guo, Junqiang;  Ai, Zongyong;  Niu, Yuyu;  Duan, Kui;  He, Jingjing;  Ren, Shuchao;  Wu, Dan;  Bai, Yun;  Shang, Zhouchun;  Dai, Xi;  Ji, Weizhi;  Li, Tianqing
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

On infection of their host, temperate viruses that infect bacteria (bacteriophages  hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration of the phage into the host genome, and dormancy (resulting in vertical transmission)(1). Previous co-culture experiments using bacteria and mutants of temperate phages that are locked in the lytic cycle have shown that CRISPR-Cas systems can efficiently eliminate the invading phages(2,3). Here we show that, when challenged with wild-type temperate phages (which can become lysogenic), type I CRISPR-Cas immune systems cannot eliminate the phages from the bacterial population. Furthermore, our data suggest that, in this context, CRISPR-Cas immune systems are maladaptive to the host, owing to the severe immunopathological effects that are brought about by imperfect matching of spacers to the integrated phage sequences (prophages). These fitness costs drive the loss of CRISPR-Cas from bacterial populations, unless the phage carries anti-CRISPR (acr) genes that suppress the immune system of the host. Using bioinformatics, we show that this imperfect targeting is likely to occur frequently in nature. These findings help to explain the patchy distribution of CRISPR-Cas immune systems within and between bacterial species, and highlight the strong selective benefits of phage-encoded acr genes for both the phage and the host under these circumstances.


CRISPR-Cas systems cannot eliminate temperate bacteriophages from bacterial populations and-in this context-the systems impose immunopathological costs on the host, creating selective pressures that may explain their patchy distribution in bacteria.


  
The global decline of freshwater megafauna 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (11) : 3883-3892
作者:  He, Fengzhi;  Zarfl, Christiane;  Bremerich, Vanessa;  David, Jonathan N. W.;  Hogan, Zeb;  Kalinkat, Gregor;  Tockner, Klement;  Jaehnig, Sonja C.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
biodiversity  conservation  distribution  extinction  population  range contraction  size  vertebrate  
Forecasting species range dynamics with process-explicit models: matching methods to applications 期刊论文
ECOLOGY LETTERS, 2019, 22 (11) : 1940-1956
作者:  Briscoe, Natalie J.;  Elith, Jane;  Salguero-Gomez, Roberto;  Lahoz-Monfort, Jose J.;  Camac, James S.;  Giljohann, Katherine M.;  Holden, Matthew H.;  Hradsky, Bronwyn A.;  Kearney, Michael R.;  McMahon, Sean M.;  Phillips, Ben L.;  Regan, Tracey J.;  Rhodes, Jonathan R.;  Vesk, Peter A.;  Wintle, Brendan A.;  Yen, Jian D. L.;  Guillera-Arroita, Gurutzeta
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Demography  mechanistic  population dynamics  process-based models  species distribution model  
Continental-scale determinants of population trends in European amphibians and reptiles 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (10) : 3504-3515
作者:  Falaschi, Mattia;  Manenti, Raoul;  Thuiller, Wilfried;  Ficetola, Gentile Francesco
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
alien species  climate change  demography  land-cover change  meta-analysis  population trends  species distribution models  
Which species, how many, and from where: Integrating habitat suitability, population genomics, and abundance estimates into species reintroduction planning 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (8) : 3729-3748
作者:  Malone, Eric W.;  Perkin, Joshuah S.;  Leckie, Brian M.;  Kulp, Matthew A.;  Hurt, Carla R.;  Walker, Donald M.
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
ecological restoration  population genomics  reintroduction planning  source stock prioritization  species distribution modeling  translocation  
Decadal changes in habitat characteristics influence population trajectories of southern elephant seals 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (12)
作者:  Hindell, Mark A.;  Sumner, Michael;  Bestley, Sophie;  Wotherspoon, Simon;  Harcourt, Robert G.;  Lea, Mary-Anne;  Alderman, Rachael;  McMahon, Clive R.
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
bio-telemetry  climate change  environmental variability  integrated marine observing system  Macquarie Island  population trends  species distribution models  
Carrying capacity in a heterogeneous environment with habitat connectivity 期刊论文
ECOLOGY LETTERS, 2017, 20 (9)
作者:  Zhang, Bo;  Kula, Alex;  Mack, Keenan M. L.;  Zhai, Lu;  Ryce, Arrix L.;  Ni, Wei-Ming;  DeAngelis, Donald L.;  Van Dyken, J. David
收藏  |  浏览/下载:19/0  |  提交时间:2019/04/09
Carrying capacity  consumer-resource model  dispersal experiment  environmental stressor  heterogeneous resource distribution  r-K relationship  spatially distributed population  
Moving beyond presence and absence when examining changes in species distributions 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (8)
作者:  Ashcroft, Michael B.;  King, Diana H.;  Raymond, Ben;  Turnbull, Johanna D.;  Wasley, Jane;  Robinson, Sharon A.
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Antarctic mosses  climate change  geographic range  negative binomial distribution  population abundance  presence-absence data  range shifts  
Temperature-nutrient interactions exacerbate sensitivity to warming in phytoplankton 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (8)
作者:  Thomas, Mridul K.;  Aranguren-Gassis, Maria;  Kremer, Colin T.;  Gould, Marilyn R.;  Anderson, Krista;  Klausmeier, Christopher A.;  Litchman, Elena
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
mechanistic species distribution model  nutrients  phytoplankton  population growth rate  R*  resources  temperature  zero net growth isocline (ZNGI)