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Nature Geoscience:慢滑事件源区的物理条件和摩擦性质 快报文章
地球科学快报,2021年第12期
作者:  王晓晨
Microsoft Word(13Kb)  |  收藏  |  浏览/下载:431/0  |  提交时间:2021/06/24
slow-slip event  physical conditions  frictional properties  
Structure of nevanimibe-bound tetrameric human ACAT1 期刊论文
NATURE, 2020, 581 (7808) : 339-U214
作者:  Ma, Xiyu;  Claus, Lucas A. N.;  Leslie, Michelle E.;  Tao, Kai;  Wu, Zhiping;  Liu, Jun;  Yu, Xiao;  Li, Bo;  Zhou, Jinggeng;  Savatin, Daniel V.;  Peng, Junmin;  Tyler, Brett M.;  Heese, Antje;  Russinova, Eugenia;  He, Ping;  Shan, Libo
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/03

The structure of human ACAT1 in complex with the inhibitor nevanimibe is resolved by cryo-electron microscopy.


Cholesterol is an essential component of mammalian cell membranes, constituting up to 50% of plasma membrane lipids. By contrast, it accounts for only 5% of lipids in the endoplasmic reticulum (ER)(1). The ER enzyme sterol O-acyltransferase 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers a long-chain fatty acid to cholesterol to form cholesteryl esters that coalesce into cytosolic lipid droplets. Under conditions of cholesterol overload, ACAT1 maintains the low cholesterol concentration of the ER and thereby has an essential role in cholesterol homeostasis(2,3). ACAT1 has also been implicated in Alzheimer'  s disease(4), atherosclerosis(5) and cancers(6). Here we report a cryo-electron microscopy structure of human ACAT1 in complex with nevanimibe(7), an inhibitor that is in clinical trials for the treatment of congenital adrenal hyperplasia. The ACAT1 holoenzyme is a tetramer that consists of two homodimers. Each monomer contains nine transmembrane helices (TMs), six of which (TM4-TM9) form a cavity that accommodates nevanimibe and an endogenous acyl-coenzyme A. This cavity also contains a histidine that has previously been identified as essential for catalytic activity(8). Our structural data and biochemical analyses provide a physical model to explain the process of cholesterol esterification, as well as details of the interaction between nevanimibe and ACAT1, which may help to accelerate the development of ACAT1 inhibitors to treat related diseases.


  
Months-long thousand-kilometre-scale wobbling before great subduction earthquakes 期刊论文
NATURE, 2020, 580 (7805) : 628-+
作者:  Son, Hyungmok;  Park, Juliana J.;  Ketterle, Wolfgang;  Jamison, Alan O.
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/13

Observed reversals in GNSS surface motions suggests greatly enhanced slab pull in the months preceding the great subduction earthquakes in Maule (Chile, 2010) and Tohoku-oki (Japan, 2011) of moment magnitudes 8.8 and 9.0.


Megathrust earthquakes are responsible for some of the most devastating natural disasters(1). To better understand the physical mechanisms of earthquake generation, subduction zones worldwide are continuously monitored with geophysical instrumentation. One key strategy is to install stations that record signals from Global Navigation Satellite Systems(2,3) (GNSS), enabling us to track the non-steady surface motion of the subducting and overriding plates before, during and after the largest events(4-6). Here we use a recently developed trajectory modelling approach(7) that is designed to isolate secular tectonic motions from the daily GNSS time series to show that the 2010 Maule, Chile (moment magnitude 8.8) and 2011 Tohoku-oki, Japan (moment magnitude 9.0) earthquakes were preceded by reversals of 4-8 millimetres in surface displacement that lasted several months and spanned thousands of kilometres. Modelling of the surface displacement reversal that occurred before the Tohoku-oki earthquake suggests an initial slow slip followed by a sudden pulldown of the Philippine Sea slab so rapid that it caused a viscoelastic rebound across the whole of Japan. Therefore, to understand better when large earthquakes are imminent, we must consider not only the evolution of plate interface frictional processes but also the dynamic boundary conditions from deeper subduction processes, such as sudden densification of metastable slab.


  
Automated radial synthesis of organic molecules 期刊论文
NATURE, 2020, 579 (7799) : 379-+
作者:  van den Brink, Susanne C.;  Alemany, Anna;  van Batenburg, Vincent;  Moris, Naomi;  Blotenburg, Marloes;  Vivie, Judith;  Baillie-Johnson, Peter;  Nichols, Jennifer;  Sonnen, Katharina F.;  Martinez Arias, Alfonso;  van Oudenaarden, Alexander
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

An automated synthesis instrument comprising a series of continuous flow modules that are radially arranged around a central switching station can achieve both linear and convergent syntheses.


Automated synthesis platforms accelerate and simplify the preparation of molecules by removing the physical barriers to organic synthesis. This provides unrestricted access to biopolymers and small molecules via reproducible and directly comparable chemical processes. Current automated multistep syntheses rely on either iterative(1-4) or linear processes(5-9), and require compromises in terms of versatility and the use of equipment. Here we report an approach towards the automated synthesis of small molecules, based on a series of continuous flow modules that are radially arranged around a central switching station. Using this approach, concise volumes can be exposed to any reaction conditions required for a desired transformation. Sequential, non-simultaneous reactions can be combined to perform multistep processes, enabling the use of variable flow rates, reuse of reactors under different conditions, and the storage of intermediates. This fully automated instrument is capable of both linear and convergent syntheses and does not require manual reconfiguration between different processes. The capabilities of this approach are demonstrated by performing optimizations and multistep syntheses of targets, varying concentrations via inline dilutions, exploring several strategies for the multistep synthesis of the anticonvulsant drug rufinamide(10), synthesizing eighteen compounds of two derivative libraries that are prepared using different reaction pathways and chemistries, and using the same reagents to perform metallaphotoredox carbon-nitrogen cross-couplings(11) in a photochemical module-all without instrument reconfiguration.


  
Environmental drivers of fire severity in extreme fire events that affect Mediterranean pine forest ecosystems 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 433: 24-32
作者:  Garcia-Llamas, Paula;  Suarez-Seoane, Susana;  Taboada, Angela;  Fernandez-Manso, Alfonso;  Quintano, Carmen;  Fernandez-Garcia, Victor;  Manuel Fernandez-Guisuraga, Jose;  Marcos, Elena;  Calvo, Leonor
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
LiDAR  Vegetation structure  Physical properties  Fire history  Weather conditions  Landsat  CBI  
Tonopah Test Range Air Monitoring: CY2013 Meteorological, Radiological, and Airborne Particulate Observations 科技报告
来源:US Department of Energy (DOE). 出版年: 2014
作者:  Mizell, Steve A;  Nikolich, George;  Shadel, Craig;  McCurdy, Greg;  Etyemezian, Vicken;  Miller, Julianne J
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/05
In 1963  the U.S. Department of Energy (DOE) (formerly the Atomic Energy Commission [AEC])  implemented Operation Roller Coaster on the Tonopah Test Range (TTR) and an adjacent area of the Nevada Test and Training Range (NTTR) (formerly the Nellis Air Force Range). This test resulted in radionuclide-contaminated soils at Clean Slate I  II  and III. This report documents observations made during on-going monitoring of radiological  meteorological  and dust conditions at stations installed adjacent to Clean Slate I and Clean Slate III and at the TTR Range Operations Control center. The primary objective of the monitoring effort is to determine if winds blowing across the Clean Slate sites are transporting particles of radionuclide-contaminated soils beyond both the physical and administrative boundaries of the sites. Results for the calendar year (CY) 2013 monitoring include: (1) the gross alpha and gross beta values from the monitoring stations are approximately equivalent to the highest values observed during the CY2012 reporting at the surrounding Community Environmental Monitoring Program (CEMP) stations (this was the latest documented data available at the time of this writing)  (2) only naturally occurring radionuclides were identified in the gamma spectral analyses  (3) the ambient gamma radiation measurements indicate that the average annual gamma exposure is similar at all three monitoring stations and periodic intervals of increased gamma values appear to be associated with storm fronts passing through the area  and (4) the concentrations of both resuspended dust and saltated sand particles generally increase with increasing wind speed. However  differences in the observed dust concentrations are likely due to differences in the soil characteristics immediately adjacent to the monitoring stations. Neither the resuspended particulate radiological analyses nor the ambient gamma radiation measurements suggest wind transport of radionuclide-contaminated soils.  
Sexual identity and living conditions : Evaluation of the relevance of living conditions and data collection 科技报告
来源:Center for International Climate and Environmental Research-Oslo (CICERO). 出版年: 2010
作者:  Gulløy, Elisabeth;  Normann, Tor Morten
收藏  |  浏览/下载:3/0  |  提交时间:2019/04/05
Living conditions  Sexual identity  Survey of living conditions  Health  Norway  Sexual attraction  Methodological challenges  Documentation  Levekår  Seksuell identitet  Helse  Homofile  Lesbiske  Mental health  Illness  Social contact  Discrimination  Physical assault