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国际智库为中国促进气候-贸易协同发展提出建议 快报文章
气候变化快报,2022年第21期
作者:  裴惠娟
Microsoft Word(13Kb)  |  收藏  |  浏览/下载:692/0  |  提交时间:2022/11/04
China  Climate-trade Nexus  International Role  
加州大学圣巴巴拉分校评选出2021年度10大海洋事件 快报文章
资源环境快报,2022年第02期
作者:  薛明媚,王金平
Microsoft Word(21Kb)  |  收藏  |  浏览/下载:691/1  |  提交时间:2022/01/31
Ocean-Climate Nexus,  Ocean Plastic Pollution  Ocean Ecosystems  
Natural resources and conflict: A meta-analysis of the empirical literature 期刊论文
ECOLOGICAL ECONOMICS, 2020, 172
作者:  Vesco, Paola;  Dasgupta, Shouro;  De Cian, Enrica;  Carraro, Carlo
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/02
Natural resources  Conflict  Meta-analysis  Meta-research  Climate-conflict nexus  Resources-driven issues  
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly 期刊论文
NATURE, 2020, 578 (7795) : 461-+
作者:  Fruchart, Michel;  Zhou, Yujie;  Vitelli, Vincenzo
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Eukaryotic cell biology depends on cullin-RING E3 ligase (CRL)-catalysed protein ubiquitylation(1), which is tightly controlled by the modification of cullin with the ubiquitin-like protein NEDD8(2-6). However, how CRLs catalyse ubiquitylation, and the basis of NEDD8 activation, remain unknown. Here we report the cryo-electron microscopy structure of a chemically trapped complex that represents the ubiquitylation intermediate, in which the neddylated CRL1(beta-TRCP) promotes the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D to its recruited substrate, phosphorylated I kappa B alpha. NEDD8 acts as a nexus that binds disparate cullin elements and the RING-activated ubiquitin-linked UBE2D. Local structural remodelling of NEDD8 and large-scale movements of CRL domains converge to juxtapose the substrate and the ubiquitylation active site. These findings explain how a distinctive ubiquitin-like protein alters the functions of its targets, and show how numerous NEDD8-dependent interprotein interactions and conformational changes synergistically configure a catalytic CRL architecture that is both robust, to enable rapid ubiquitylation of the substrate, and fragile, to enable the subsequent functions of cullin-RING proteins.


A cryo-electron microscopy structure provides insights into the activation of cullin-RING E3 ligases by NEDD8 and the consequent catalysis of ubiquitylation reactions.


  
Monitoring hydropower reliability in Malawi with satellite data and machine learning 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (1)
作者:  Falchetta, Giacomo;  Kasamba, Chisomo;  Parkinson, Simon C.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
hydroelectricity  vulnerability  extreme hydroclimatic events  energy-climate-water nexus  random forests  remote sensing  
Introduction to the Water-Soil-Air-Plant-Human Nexus: Modeling and Observing Complex Land Surface Systems at River Basin Scale 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Li, Xin;  Xie, Zhenghui
收藏  |  浏览/下载:13/0  |  提交时间:2020/02/17
water-soil-air-plant-human nexus  human-nature system  river basin  modeling  observation  Heihe River Basin  
Water security implications of coal-fired power plants financed through China's Belt and Road Initiative 期刊论文
ENERGY POLICY, 2019, 132: 1101-1109
作者:  Alkon, Meir;  He, Xiaogang;  Paris, Aubrey R.;  Liao, Wenying;  Hodson, Thomas;  Wanders, Niko;  Wang, Yaoping
收藏  |  浏览/下载:25/0  |  提交时间:2019/11/27
Sustainability  Belt and Road Initiative  Water-energy nexus  Water resources  Water security  Coal  CPEC  Energy  
Evidence, ideology, and the policy of community management in Africa 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (8)
作者:  Whaley, Luke;  MacAllister, Donald John;  Bonsor, Helen;  Mwathunga, Evance;  Banda, Sembeyawo;  Katusiime, Felece;  Tadesse, Yehualaeshet;  Cleaver, Frances;  MacDonald, Alan
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
groundwater  development  interdisciplinary  governance  nexus  ideology  policy  
A regional assessment of the water embedded in the US electricity system 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (8)
作者:  Peer, Rebecca A. M.;  Grubert, Emily;  Sanders, Kelly T.
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
energy-water nexus  water consumption  regionalization  
A 40-year review of food-energy-water nexus literature and its application to the urban scale 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (7)
作者:  Newell, Joshua P.;  Goldstein, Benjamin;  Foster, Alec
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/27
food  energy  water  nexus  urban metabolism  literature review